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1. (WO2007081516) TUMOR ACTIVATED PRODRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/081516 International Application No.: PCT/US2006/048680
Publication Date: 19.07.2007 International Filing Date: 19.12.2006
IPC:
A61K 38/00 (2006.01) ,A61K 38/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants: DENMEADE, Samuel, R.[US/US]; US (UsOnly)
ISAACS, John, Tod[US/US]; US (UsOnly)
GENSPERA, INC.[US/US]; 12100 Wilshire Blvd. 8Th Floor Los angeles, CA 90025, US (AllExceptUS)
Inventors: DENMEADE, Samuel, R.; US
ISAACS, John, Tod; US
Agent: REED, Michael. ; Paul, Hastings, Janofsky & Walker LLP P.O. Box 919092 San Diego, CA 92191-9092, US
Priority Data:
11/328,49106.01.2006US
Title (EN) TUMOR ACTIVATED PRODRUGS
(FR) PROMEDICAMENTS SPECIFIQUES A DES TISSUS
Abstract:
(EN) The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO: l);Gly - Lys - Ser - GIn - Tyr - GIn (SEQ ID NO:2); and GIy - Ser- Ala - Lys - Tyr - GIn (SEQ ID NO:3) wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of prostate specific antigen (PSA). The invention further provides methods of making and using the claimed compositions.
(FR) L'invention concerne des compositions contenant un promédicament. Ce promédicament renferme un médicament actif sur le plan thérapeutique; et un peptide sélectionné dans le groupe constitué des séquences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO: l);Gly - Lys - Ser - GIn - Tyr - GIn (SEQ ID NO:2); et GIy - Ser- Ala - Lys - Tyr - GIn (SEQ ID NO:3) dans lesquelles le peptide est lié à un médicament actif sur le plan thérapeutique afin d'inhiber l'activité thérapeutique du médicament, et dans lesquelles le médicament actif sur le plan thérapeutique est clivé par le peptide par protéolyse d'une enzyme à activité protéolytique de l'antigène spécifique de la prostate (PSA). L'invention concerne également des procédés de fabrication et d'utilisation des compositions de l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)