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1. (WO2007080622) LUMINESCENT STEM CELLS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/080622    International Application No.:    PCT/IT2007/000021
Publication Date: 19.07.2007 International Filing Date: 10.01.2007
IPC:
C07K 14/435 (2006.01), C12N 15/12 (2006.01), G01N 33/68 (2006.01)
Applicants: AXXAM S.P.A. [IT/IT]; San Raffaele Biomedical Science Park, Via Olgettina 58, I-20132 Milano (IT) (For All Designated States Except US).
CAINARCA, Silvia [IT/IT]; (IT) (For US Only).
NUCCI, Cinzia [IT/IT]; (IT) (For US Only).
CORAZZA, Sabrina [IT/IT]; (IT) (For US Only).
LOHMER, Stefan [DE/IT]; (IT) (For US Only)
Inventors: CAINARCA, Silvia; (IT).
NUCCI, Cinzia; (IT).
CORAZZA, Sabrina; (IT).
LOHMER, Stefan; (IT)
Agent: CAPASSO, Olga; De Simone & Partners S.p.A., Via Vincenzo Bellini, 20, IT-00198 ROMA (IT)
Priority Data:
06 000 452.0 11.01.2006 EP
06 022 458.1 27.10.2006 EP
Title (EN) LUMINESCENT STEM CELLS AND USES THEREOF
(FR) CELLULES SOUCHES LUMINESCENTES ET LEURS UTILISATIONS
Abstract: front page image
(EN)It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation; methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target; uses of stable recombinant stem cells for in vitro testing of toxicity and/ teratology of a substance.
(FR)La présente invention concerne une cellule souche recombinante stable capable d'exprimer une apophotoprotéine et de produire un signal bioluminescent en présence d'un chromophore adéquat servant de substrat en réponse à une variation de la concentration en calcium intracellulaire ; des procédés d'identification d'agents modulant la différenciation des cellules souches en une lignée cellulaire spécifique ; des procédés d'identification d'un ligand capable de stimuler une lignée cellulaire cible spécifique ; des procédés d'identification d'un antagoniste dirigé contre un ligand connu pour stimuler une lignée cellulaire cible spécifique ; des utilisations de cellules souches recombinantes stables pour le test de la toxicité et/ou de la tératogénicité d'une substance in vitro.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)