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1. (WO2007080382) MORPHOLINO PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/080382    International Application No.:    PCT/GB2007/000037
Publication Date: 19.07.2007 International Filing Date: 08.01.2007
IPC:
C07D 239/42 (2006.01), C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 403/10 (2006.01), C07D 403/12 (2006.01), C07D 405/04 (2006.01), C07D 405/10 (2006.01), C07D 405/14 (2006.01), C07D 407/14 (2006.01), C07D 409/04 (2006.01), C07D 413/10 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MK, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1K 1LN (GB) (MG only).
PIKE, Kurt, Gordon [GB/GB]; (GB) (For US Only).
FINLAY, Maurice, Raymond, Verschoyle [GB/GB]; (GB) (For US Only).
FILLERY, Shaun, Michael [GB/GB]; (GB) (For US Only).
DISHINGTON, Allan, Paul [GB/GB]; (GB) (For US Only)
Inventors: PIKE, Kurt, Gordon; (GB).
FINLAY, Maurice, Raymond, Verschoyle; (GB).
FILLERY, Shaun, Michael; (GB).
DISHINGTON, Allan, Paul; (GB)
Agent: GLOBAL INTELLECTUAL PROPERTY; Astrazeneca Ab, S-151 85 Södertälje (SE)
Priority Data:
0600483.2 11.01.2006 GB
0616747.2 24.08.2006 GB
Title (EN) MORPHOLINO PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY
(FR) DÉRIVÉS DE MORPHOLINOPYRIMIDINE ET LEUR UTILISATION THÉRAPEUTIQUE
Abstract: front page image
(EN)A compound of formula (I) or a salt, ester or prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme.
(FR)L'invention concerne un composé de formule (I) ou un sel, ester ou promédicament de celui-ci, des procédés pour les préparer, des compositions pharmaceutiques les contenant, ainsi que leur utilisation thérapeutique, par exemple dans le traitement d'une maladie proliférative telle que le cancer et en particulier une maladie médiée par une mTOR kinase et/ou par une ou plusieurs enzymes PI3K.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)