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1. (WO2007080159) PYRIDINE-, ISOXAZOLE, THIOPHENECARBOXAMIDE COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/080159 International Application No.: PCT/EP2007/050157
Publication Date: 19.07.2007 International Filing Date: 08.01.2007
IPC:
C07D 213/62 (2006.01) ,C07D 261/08 (2006.01) ,C07D 333/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62
Oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
261
Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
02
not condensed with other rings
06
having two or more double bonds between ring members or between ring members and non-ring members
08
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
Applicants:
BRANCH, Clive, Leslie [GB/GB]; GB (UsOnly)
MARSHALL, Howard [GB/GB]; GB (UsOnly)
MACRITCHIE, Jackie [GB/GB]; GB (UsOnly)
PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
SPADA, Simone [IT/IT]; IT (UsOnly)
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
Inventors:
BRANCH, Clive, Leslie; GB
MARSHALL, Howard; GB
MACRITCHIE, Jackie; GB
PORTER, Roderick, Alan; GB
SPADA, Simone; IT
Agent:
KONDO, Rie ; GlaxoSmithKline Corporate Intellectual Property (cn925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
0600427.910.01.2006GB
Title (EN) PYRIDINE-, ISOXAZOLE, THIOPHENECARBOXAMIDE COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF
(FR) COMPOSÉS ACTIFS AU NIVEAU DU TRANSPORTEUR DE GLYCINE GLYT1 ET UTILISATIONS
Abstract:
(EN) The present invention relates to compounds of formula (I), salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I), wherein R1, R2, R3, R4, R5, R6 and n are as defined in the description.
(FR) La présente invention concerne des composés de formule (I), ou des sels ou solvates desdits composés, ainsi que leur utilisation dans la fabrication de médicaments destinés au traitement de troubles neurologiques et neuropsychiatriques, en particulier les troubles tels que les psychoses, la démence ou le déficit d'attention. La présente invention concerne en outre des procédés permettant d'élaborer ces composés ainsi que les formules pharmaceutiques correspondantes. Formule (I) où R1, R2, R3, R4, R5, R6 et n sont tels que définis dans la description de l'invention.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)