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1. (WO2007079141) METHOD OF IDENTIFYING COMPOUNDS USEFUL TO TREAT NEURONAL DEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/079141    International Application No.:    PCT/US2006/049424
Publication Date: 12.07.2007 International Filing Date: 28.12.2006
IPC:
G01N 33/68 (2006.01), A61K 31/00 (2006.01), A61K 31/085 (2006.01), A61K 31/09 (2006.01)
Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION [US/US]; Iowa Centers for Enterprise, 2660 University Capitol Centre, 200 S. Capitol Street, Iowa City, Iowa 52242-5500 (US) (For All Designated States Except US).
ENGELHARDT, John F. [US/US]; (US) (For US Only).
ZHOU, Weihong [US/US]; (US) (For US Only).
HARRAZ, Maged M. [EG/US]; (US) (For US Only).
MARDEN, Jennifer J. [US/US]; (US) (For US Only)
Inventors: ENGELHARDT, John F.; (US).
ZHOU, Weihong; (US).
HARRAZ, Maged M.; (US).
MARDEN, Jennifer J.; (US)
Agent: STEFFEY, Charles E.; Schwegman, Lundberg & Woessner, P.A., P.O. Box 2938, Minneapolis, Minnesota 55402 (US)
Priority Data:
60/755,337 30.12.2005 US
Title (EN) METHOD OF IDENTIFYING COMPOUNDS USEFUL TO TREAT NEURONAL DEGENERATIVE DISEASES
(FR) PROCEDE D'IDENTIFICATION DE COMPOSES UTILES POUR LE TRAITEMENT DE MALADIES DEGENERATIVES NEURONALES
Abstract: front page image
(EN)Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.
(FR)La présente invention concerne des procédés d'identification d'agents inhibiteurs d'espèces réactives de l'oxygène par la modification de la liaison d'une GTPase telle que Rac à la dismutase superoxyde, des agents identifiés par ce procédé, et des procédés d'utilisation de composés inhibiteurs d'espèces réactives de l'oxygène pour la prévention ou de traitement de maladies dégénératives neuronales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)