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1. (WO2007079075) PHOSPHORYLATED COP1 MOLECULES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/079075    International Application No.:    PCT/US2006/049262
Publication Date: 12.07.2007 International Filing Date: 21.12.2006
IPC:
C12Q 1/25 (2006.01), G01N 33/50 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080 (US) (For All Designated States Except US).
DORNAN, David [GB/US]; (US) (For US Only)
Inventors: DORNAN, David; (US)
Agent: DREGER, Ginger, R.; Goodwin Procter LLP, 135 Commonwealth Drive, Menlo Park, CA 94025 (US)
Priority Data:
60/755,412 31.12.2005 US
Title (EN) PHOSPHORYLATED COP1 MOLECULES AND USES THEREOF
(FR) MOLÉCULES DE COP1 PHOSPHORYLÉES ET LEURS UTILISATIONS
Abstract: front page image
(EN)The invention provides COP1 molecules and modulators of COP1 activity and methods of using them, including diagnostic and therapeutic uses thereof. Such molecules can be useful for detecting DNA damage and modulating the response to DNA damage and p53 activity in subjects. The invention also provides reagents and kits for use in screening for test compounds that can modulate COP1 activity.
(FR)L'invention concerne des molécules de COP1 et des modulateurs de l'activité du COP1, ainsi que des procédés pour les utiliser, y compris leurs utilisations diagnostiques et thérapeutiques. Ces molécules peuvent être utiles pour détecter la dégradation d'ADN et moduler la réponse à la dégradation de l'ADN et à l'activité de la p53 chez les sujets. L'invention concerne également des réactifs et des kits utilisables pour cribler des composés de test capables de moduler l'activité du COP1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)