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1. (WO2007078263) THE STRAIN STREPTOMYCES TOXYTRICINI LIPSTATIN-PRODUCING MICROORGANISM AND PREPARATION OF LIPSTATIN WITH INSCRIBED STRAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/078263    International Application No.:    PCT/SK2006/050008
Publication Date: 12.07.2007 International Filing Date: 18.12.2006
IPC:
C12P 17/02 (2006.01)
Applicants: BIOTIKA A.S. [SK/SK]; 976 13 Slovenska Lupca (SK) (For All Designated States Except US).
VARGA, Ivan [SK/--]; (SK) (For US Only).
GONDOVA, Blanka [SK/--]; (SK) (For US Only).
GAJDOSIKOVA, Jana [SK/--]; (SK) (For US Only).
KOVACOVA, Ludmila [SK/--]; (SK) (For US Only)
Inventors: VARGA, Ivan; (SK).
GONDOVA, Blanka; (SK).
GAJDOSIKOVA, Jana; (SK).
KOVACOVA, Ludmila; (SK)
Agent: DOLANSKA, Elena; DOLANSKA Patent and Trademark, Agency, Radlinskeho 9, 811 07 Bratislava (SK)
Priority Data:
PP 0002-2006 03.01.2006 SK
Title (EN) THE STRAIN STREPTOMYCES TOXYTRICINI LIPSTATIN-PRODUCING MICROORGANISM AND PREPARATION OF LIPSTATIN WITH INSCRIBED STRAIN
(FR) SOUCHE DE MICRO-ORGANISME STREPTOMYCES TOXYTRICINI PRODUISANT UNE LIPSTATINE ET PRÉPARATION D’UNE LIPSTATINE AU MOYEN DE LADITE SOUCHE
Abstract: front page image
(EN)Technical solution is related to industry production microorganism Streptomyces toxytricini CCM 7349 and method of lipstatin biotechnology preparation by this strain. Production strain listed above with use of two step vegetative inoculum produce lipstatin in concentration from 3,0 to 3,2 g/kg fermentation broth after 180 till 230 hours of cultivation under temperature at 28°C, under optimal mixing above 450 rpm, aeration 1 till 1,25 vvm and optimal addition of linoleic acid and 8% solution of L-Leucine.
(FR)L’invention concerne une solution technique relative à la production industrielle de micro-organisme toxytricini Streptomyces CCM 7349, et une méthode de préparation biotechnologique de lipstatine a l’aide de ladite souche. La souche productrice décrite ici utilise deux étapes d’inoculum végétatif pour produire une lipstatine à une concentration de 3,0 à 3,2 g/kg de bouillon de fermentation après 180 à 230 heures de culture à une température de 28°C, sous des conditions optimales de mélange supérieur à 450 tpm, d’aération de 1 à 1,25 VVM et avec une addition optimale d'acide linoléique et d’une solution à 8% de L-leucine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)