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1. (WO2007077949) HETEROCYCLIC JANUS KINASE 3 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/077949    International Application No.:    PCT/JP2006/326327
Publication Date: 12.07.2007 International Filing Date: 25.12.2006
IPC:
C07D 471/04 (2006.01), C07D 471/14 (2006.01), A61P 37/06 (2006.01), A61P 11/06 (2006.01), A61P 17/00 (2006.01), A61P 25/28 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61K 31/437 (2006.01), C07D 451/04 (2006.01)
Applicants: ASTELLAS PHARMA INC. [JP/JP]; 3-11 Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo 103-8411 (JP) (For All Designated States Except US).
INOUE, Takayuki [JP/JP]; (JP) (For US Only).
TANAKA, Akira [JP/JP]; (JP) (For US Only).
NAKAI, Kazuo [JP/JP]; (JP) (For US Only).
SASAKI, Hiroshi [JP/JP]; (JP) (For US Only).
TAKAHASHI, Fumie [JP/JP]; (JP) (For US Only).
SHIRAKAMI, Shohei [JP/JP]; (JP) (For US Only).
HATANAKA, Keiko [JP/JP]; (JP) (For US Only).
NAKAJIMA, Yutaka [JP/JP]; (JP) (For US Only).
MUKOYOSHI, Koichiro [JP/JP]; (JP) (For US Only).
HAMAGUCHI, Hisao [JP/JP]; (JP) (For US Only).
KUNIKAWA, Shigeki [JP/JP]; (JP) (For US Only).
HIGASHI, Yasuyuki [JP/JP]; (JP) (For US Only)
Inventors: INOUE, Takayuki; (JP).
TANAKA, Akira; (JP).
NAKAI, Kazuo; (JP).
SASAKI, Hiroshi; (JP).
TAKAHASHI, Fumie; (JP).
SHIRAKAMI, Shohei; (JP).
HATANAKA, Keiko; (JP).
NAKAJIMA, Yutaka; (JP).
MUKOYOSHI, Koichiro; (JP).
HAMAGUCHI, Hisao; (JP).
KUNIKAWA, Shigeki; (JP).
HIGASHI, Yasuyuki; (JP)
Agent: MORITA, Hiroshi; c/o Astellas Pharma Inc., 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 103-8411 (JP)
Priority Data:
2005-378858 28.12.2005 JP
Title (EN) HETEROCYCLIC JANUS KINASE 3 INHIBITORS
(FR) INHIBITEURS HETEROCYCLIQUES DE LA JANUS KINASE 3
Abstract: front page image
(EN)The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
(FR)La présente invention concerne un composé de formule (I) doté d’une excellente activité d’inhibition de JAK3 et utile en tant que principe actif d’un médicament destiné à traiter et/ou à prévenir diverses maladies immunitaires, y compris les maladies auto-immunes, les maladies inflammatoires et les maladies allergiques. Le composé selon la présente invention présente une activité d’inhibition vis-à-vis de JAK3 et est à ce titre utile en tant que principe actif d’un médicament destiné à traiter ou à prévenir des maladies induites par la transmission indésirable de signaux de cytokine (p. ex., rejet lors d’une greffe d’organe/de tissu, maladies auto-immunes, sclérose en plaques, polyarthrite rhumatoïde, psoriasis, asthme, dermatite atopique, maladie d’Alzheimer et maladies athéroscléreuses), ou des maladies induites par une transmission anormale de signaux de cytokine (p. ex., cancer et leucémie).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)