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1. (WO2007077580) IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/077580    International Application No.:    PCT/IN2007/000003
Publication Date: 12.07.2007 International Filing Date: 04.01.2007
Chapter 2 Demand Filed:    16.08.2007    
IPC:
C07D 333/04 (2006.01)
Applicants: MSN LABORATORIES LIMITED [IN/IN]; SURVEY NO: 317 & 323 Rudraram (Vill) Patancheru (M) Medak (Dist) Hyderabad 502 329 (IN) (For All Designated States Except US).
SATYANARAYANA REDDY, Manne [IN/IN]; (IN) (For US Only).
KISHORE KUMAR, Muppa [IN/IN]; (IN) (For US Only).
THIRUMALAI RAJAN, Srinivasan [IN/IN]; (IN) (For US Only).
SHYLA PRASAD, Durgadas [IN/IN]; (IN) (For US Only)
Inventors: SATYANARAYANA REDDY, Manne; (IN).
KISHORE KUMAR, Muppa; (IN).
THIRUMALAI RAJAN, Srinivasan; (IN).
SHYLA PRASAD, Durgadas; (IN)
Priority Data:
30/CHE/2006 06.01.2006 IN
2296/CHE/2006 11.12.2006 IN
Title (EN) IMPROVED PROCESS FOR PURE DULOXETINE HYDROCHLORIDE
(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE CHLORHYDRATE DE DULOXETINE PUR
Abstract: front page image
(EN)A process for the preparation of pure Duloxetine hydrochloride comprises the steps of : a) reacting 1-(thiophen-2-yl)ethanone with dimethylamine hydrochloride, b) purifying the component in a solvent, c) reducing the component with an alkali metal borohydride, d) resolving the compound with a chiral acid, and treating the obtained compound with weak inorganic base, e) reacting the compound to give Duloxetine oxalate salt and f) converting the Duloxetine salt into its hydrochloride salt. Further the purifications of the obtained compound and of two intermediate products are described.
(FR)La présente invention concerne un procédé amélioré pour la préparation de composé de chlorhydrate de duloxétine pur comprenant les étapes suivantes: a) la réaction de 1-(thiophen-2-yl)éthanone avec du chlorhydrate de diméthylamine, b) purification d'un composé dans un solvant, c) réduction du composé avec un borohydrure de métal alcalin, d) résolution du composé avec un acide chiral, et traitement du composé obtenu avec une base organique faible, e) réaction du composé pour obtenir du sel oxalate de duloxétine, et f) conversion du sel de duloxétine en son sel de chlorhydrate. L'invention concerne également les procédés de purifications du composé obtenu et de deux produits intermédiaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)