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Pub. No.:    WO/2007/077510    International Application No.:    PCT/IB2006/055010
Publication Date: 12.07.2007 International Filing Date: 21.12.2006
C07D 233/14 (2006.01), C07D 233/60 (2006.01), C07D 233/61 (2006.01), C07D 401/12 (2006.01), A61K 31/4164 (2006.01), A61K 31/4439 (2006.01), A61P 1/00 (2006.01), A61P 11/00 (2006.01), A61P 13/00 (2006.01)
Applicants: RANBAXY LABORATORIES LIMITED [IN/IN]; Plot No. 90, Sector - 32, Gurgaon 122001, Haryana (IN) (For All Designated States Except US).
KUMAR, Naresh [IN/IN]; (IN) (For US Only).
KAUR, Jaskiran [IN/IN]; (IN) (For US Only).
PALLE, Venkata P. [US/IN]; (IN) (For US Only).
BHATT, Beenu [IN/AU]; (AU) (For US Only).
JINDAL, Shelly [IN/IN]; (IN) (For US Only).
CHUGH, Anita [IN/IN]; (IN) (For US Only).
GUPTA, Suman [IN/IN]; (IN) (For US Only).
RAY, Abhijit [IN/IN]; (IN) (For US Only).
MALHOTRA, Shivani [IN/IN]; (IN) (For US Only).
SHIRUMALLA, Raj Kumar [IN/IN]; (IN) (For US Only)
Inventors: KUMAR, Naresh; (IN).
KAUR, Jaskiran; (IN).
PALLE, Venkata P.; (IN).
BHATT, Beenu; (AU).
JINDAL, Shelly; (IN).
CHUGH, Anita; (IN).
GUPTA, Suman; (IN).
RAY, Abhijit; (IN).
MALHOTRA, Shivani; (IN).
RANBAXY LABORATORIES LIMITED; c/o Deshmukh, Jay, R., 600 College Road East, Suite 2100, Princeton, New Jersey 08540 (US)
Priority Data:
3521/DEL/2005 30.12.2005 IN
1557/DEL/2006 03.07.2006 IN
Abstract: front page image
(EN)Compounds of Formula (I), wherein represents a single bond when G is -OH and double bond when G is -O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, -NH, -NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.
(FR)La présente invention concerne de manière générale des antagonistes des récepteurs muscariniques qui sont utiles entre autres pour le traitement de diverses maladies des systèmes respiratoire, urinaire et gastro-intestinal médiées par les récepteurs muscariniques. L'invention concerne également le procédé de préparation des composés présentés, de compositions pharmaceutiques contenant ces composés, ainsi que les procédés de traitement de maladies médiées par les récepteurs muscariniques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)