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1. (WO2007077186) PDF INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/077186    International Application No.:    PCT/EP2006/070234
Publication Date: 12.07.2007 International Filing Date: 28.12.2006
IPC:
C07D 403/04 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), C07D 417/04 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 491/04 (2006.01), C07D 498/04 (2006.01), A61K 31/435 (2006.01), A61K 31/495 (2006.01), A61K 31/41 (2006.01), A61P 31/04 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (For All Designated States Except US).
PICHOTA, Arkadius [DE/SG]; (SG) (For US Only).
DURAISWAMY, Jeyaraj [IN/SG]; (SG) (For US Only).
YIN, Zheng [CN/SG]; (SG) (For US Only).
KELLER, Thomas Hugo [CH/SG]; (SG) (For US Only).
SCHREIBER, Mark [GB/SG]; (SG) (For US Only)
Inventors: PICHOTA, Arkadius; (SG).
DURAISWAMY, Jeyaraj; (SG).
YIN, Zheng; (SG).
KELLER, Thomas Hugo; (SG).
SCHREIBER, Mark; (SG)
Agent: SPILLMANN, Adrian; NOVARTIS AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
200508608-7 30.12.2005 SG
Title (EN) PDF INHIBITORS
(FR) INHIBITEURS DE PDF
Abstract: front page image
(EN)The invention relates to novel compounds that are inhibitors of peptidyl deformylase (PDF). The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and uses of the compounds are also disclosed.
(FR)La présente invention concerne de nouveaux composés qui sont des inhibiteurs de peptidyl déformylase (PDF). Les composés sont utiles en tant qu'antimicrobiens et antibiotiques. Les composés de l'invention présentent une inhibition sélective de la peptidyl déformylase par rapport à d'autres métalloprotéases telles que les MMP. La présente invention concerne en outre des procédés de préparation et des utilisations des composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)