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1. (WO2007076358) PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/076358    International Application No.:    PCT/US2006/062303
Publication Date: 05.07.2007 International Filing Date: 19.12.2006
IPC:
A61K 9/10 (2006.01)
Applicants: ALCON, INC. [CH/CH]; Bösch 69, P.O. Box 62, CH-6331 Hünenberg (CH) (For All Designated States Except US).
GHOSH, Malay [IN/US]; (US) (For US Only).
HAN, Wesley, Wehsin [US/US]; (US) (For US Only).
LIN, Way-yu [US/US]; (US) (For US Only).
BINGAMAN, David, P. [US/US]; (US) (For All Designated States Except US).
ROBERTSON, Stella, M. [US/US]; (US) (For All Designated States Except US)
Inventors: GHOSH, Malay; (US).
HAN, Wesley, Wehsin; (US).
LIN, Way-yu; (US)
Agent: SCHULTZ, Teresa, J.; ALCON RESEARCH, LTD., IP Legal, Mail Code TB4-8, 6201 South Freeway, Fort Worth, Texas 76134-2099 (US)
Priority Data:
60/753,713 23.12.2005 US
Title (EN) PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
(FR) PREPARATION PHARMACEUTIQUE POUR L'ADMINISTRATION, DANS L'OEIL, DE COMPOSES INHIBITEURS DES RÉCEPTEURS TYROSINE KINASES (RTKI)
Abstract: front page image
(EN)The present invention relates to development of efficacious intravitreal pharmaceutical compositions comprising a poorly water soluble agent with anti-angiogenic and/or anti vascular leakage properties in a therapeutically effective amount and a co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability.
(FR)La présente invention concerne la préparation de compositions pharmaceutiques intravitréennes efficaces comportant une quantité thérapeutiquement efficace d'un agent faiblement soluble dans l'eau présentant des propriétés anti-angiogéniques et/ou anti-fuites vasculaires et une quantité appropriée d'un cosolvant pour traiter ou prévenir des maladies dues à une néovascularisation oculaire et à une perméabilité vasculaire accrue.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)