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1. (WO2007075199) USE OF ALKALINE PHOSPHATASE TO MAINTAIN HEALTHY TISSUE MASS IN MAMMALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/075199    International Application No.:    PCT/US2006/030753
Publication Date: 05.07.2007 International Filing Date: 08.08.2006
IPC:
A61K 38/46 (2006.01)
Applicants: ZOLTAN LABORATORIES LLC [US/US]; 404 20th Street SW, Austin, MN 55912 (US) (For All Designated States Except US).
KISS, Zoltan [HU/US]; (US) (For US Only)
Inventors: KISS, Zoltan; (US)
Agent: D'SOUZA, Tanya; 90 South Seventh Street, 2200 Wells Fargo Center, Minneapolis, MN 55402-3901 (US)
Priority Data:
60/754,374 28.12.2005 US
Title (EN) USE OF ALKALINE PHOSPHATASE TO MAINTAIN HEALTHY TISSUE MASS IN MAMMALS
(FR) UTILISATION DE PHOSPHATASE ALCALINE POUR LE MAINTIEN DE LA MASSE DE TISSUS SAINS CHEZ DES MAMMIFERES
Abstract: front page image
(EN)Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, adipose and other tissues. The ability of alkaline phosphatase to selectively enhance the survival of healthy cells and increase protein synthesis has many therapeutic applications. The use of alkaline phosphatase may prevent the loss of body weight and muscle mass typically experienced by diseased (such as cancer) or aging patients, or developing fetuses subjected to harmful conditions, or by patients who are treated with a toxic therapy including chemotherapy.
(FR)Des modes de réalisation de la présente invention concernent l'utilisation d'une phosphatase alcaline placentaire, et d'autres membres de la famille des phosphatases alcalines, afin d'augmenter la synthèse de protéines dans le muscle et le taux de survie de cellules différenciées non cancéreuses dans le muscle, les cellules adipeuses et d'autres tissus. La capacité de la phosphatase alcaline à augmenter sélectivement le taux de survie de cellules saines et la synthèse de protéines offre de nombreuses applications thérapeutiques. L'utilisation de la phosphatase alcaline peut permettre d'éviter une perte de masse corporelle et de masse musculaire chez des patients malades (atteints d'un cancer, par exemple) ou vieillissants, ou chez des foetus en développement soumis à des conditions nuisibles, ou chez des patients soumis à un traitement toxique, y compris une chimiothérapie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)