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Machine translation
1. (WO2007073774) GENOTOXIC TESTING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/073774    International Application No.:    PCT/EP2005/057158
Publication Date: 05.07.2007 International Filing Date: 23.12.2005
IPC:
C12Q 1/68 (2006.01)
Applicants: UNIVERSITA' DEGLI STUDI DI TORINO [IT/IT]; VIA VERDI 8, I-10126 Torino (IT) (For All Designated States Except US).
CABODI, Sara [IT/IT]; (IT) (For US Only).
DEFILIPPI, Paola [IT/IT]; (IT) (For US Only)
Inventors: CABODI, Sara; (IT).
DEFILIPPI, Paola; (IT)
Agent: FREYRIA FAVA, Cristina; Buzzi, Notaro & Antonielli d'Oulx S.r.l., Via Maria Vittoria 18, I-10123 Torino (IT)
Priority Data:
Title (EN) GENOTOXIC TESTING
(FR) ESSAIS DE GÉNOTOXICITÉ
Abstract: front page image
(EN)The present invention concerns the use of P130Cas/BCAR1 protein and/or encoding gene for the screening for substances useful in the treatment of tumors. The present invention also concerns a method for the diagnosis of malignant cell growth comprising the measuring the expression of P130Cas/BCAR1 gene. The invention concerns also non-human transgenic animals as model study for human pathologies, preferably cancer, being transgenic for having altered P130Cas/BCAR1 and Neu-T expression.
(FR)La présente invention concerne l'utilisation de la protéine P130Cas/BCAR1 et/ou de son gène codant pour le criblage de substances utiles dans le traitement de tumeurs. La présente invention concerne également un procédé de diagnostic de la croissance de cellules malignes qui comprend la mesure de l'expression du gène de P130Cas/BCAR1. L'invention concerne en outre des animaux transgéniques non humains servant de modèles d'étude de pathologies humaines, de préférence le cancer, qui sont transgéniques du fait qu'ils présentent une expression modifiée de P130Cas/BCAR1 et de Neu-T.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)