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1. WO2007071738 - CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS

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Publication Number WO/2007/071738
Publication Date 28.06.2007
International Application No. PCT/EP2006/070029
International Filing Date 20.12.2006
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 7/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
Applicants
  • NOVARTIS AG [CH]/[CH] (AllExceptUS)
  • BAESCHLIN, Daniel Kaspar [CH]/[CH] (UsOnly)
  • CLARK, David Edward [GB]/[GB] (UsOnly)
  • DUNSDON, Stephen John [GB]/[GB] (UsOnly)
  • FENTON, Garry [GB]/[GB] (UsOnly)
  • FILLMORE, Amanda [GB]/[GB] (UsOnly)
  • HARRIS, Neil Victor [GB]/[GB] (UsOnly)
  • HIGGS, Christopher [GB]/[GB] (UsOnly)
  • HURLEY, Christopher Antony [GB]/[GB] (UsOnly)
  • KRINTEL, Sussie Lerche [DK]/[GB] (UsOnly)
  • MACKENZIE, Robert Edward [GB]/[GB] (UsOnly)
  • OSTERMANN, Nils [DE]/[DE] (UsOnly)
  • SIROCKIN, Finton [FR]/[FR] (UsOnly)
  • SUTTON, Jonathan Mark [GB]/[GB] (UsOnly)
Inventors
  • BAESCHLIN, Daniel Kaspar
  • CLARK, David Edward
  • DUNSDON, Stephen John
  • FENTON, Garry
  • FILLMORE, Amanda
  • HARRIS, Neil Victor
  • HIGGS, Christopher
  • HURLEY, Christopher Antony
  • KRINTEL, Sussie Lerche
  • MACKENZIE, Robert Edward
  • OSTERMANN, Nils
  • SIROCKIN, Finton
  • SUTTON, Jonathan Mark
Agents
  • LIGIBEL, Jean-Marc
Priority Data
60/753,38223.12.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS
(FR) COMPOSES HETEROCYCLIQUES CONDENSES UTILES EN TANT QU’INHIBITEURS DE DPP-IV
front page image
Abstract
(EN) The invention provides novel deazaxanthine and deazahypoxanthine compounds, of formula (I), wherein X is -CH= and Y is =N-; or X is -C(O)- and Y is -N(R3)-; The compounds may be useful in the therapy of diseases and conditions in wich dipeptidylpeptidase-IV (DPP-IV) is implicated.
(FR) L’invention concerne de nouveaux composés de déazaxanthine et de déazahypoxanthine, de formule (I), dans laquelle X représente -CH= et Y représente =N- ; ou X représente -C(O)- et Y représente -N(R3)-. Ces composés peuvent être utiles pour le traitement de maladies et d’états impliquant la dipeptidylpeptidase-IV (DPP-IV).
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