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1. WO2007071646 - NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES

Publication Number WO/2007/071646
Publication Date 28.06.2007
International Application No. PCT/EP2006/069830
International Filing Date 18.12.2006
IPC
C07D 241/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Nitrogen atoms
C07D 403/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
A61K 31/497 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965Non-condensed pyrazines
497containing further heterocyclic rings
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
Applicants
  • JANSSEN PHARMACEUTICA N.V. [BE]/[BE] (AllExceptUS)
  • ANDRÉS-GIL, José, Ignacio [ES]/[ES] (UsOnly)
  • ALCÁZAR-VACA, Manuel, Jesús [ES]/[ES] (UsOnly)
  • ÁLVAREZ-ESCOBAR, Rosa, María [ES]/[ES] (UsOnly)
  • OYARZABAL SANTAMARINA, Julen [ES]/[ES] (UsOnly)
  • DAUTZENBERG, Frank, Matthias [DE]/[BE] (UsOnly)
  • MACRITCHIE, Jacqueline [GB]/[GB] (UsOnly)
  • SIMPSON, Donald [GB]/[GB] (UsOnly)
  • MARTINEZ GONZALEZ, Sonia [ES]/[ES] (UsOnly)
Inventors
  • ANDRÉS-GIL, José, Ignacio
  • ALCÁZAR-VACA, Manuel, Jesús
  • ÁLVAREZ-ESCOBAR, Rosa, María
  • OYARZABAL SANTAMARINA, Julen
  • DAUTZENBERG, Frank, Matthias
  • MACRITCHIE, Jacqueline
  • SIMPSON, Donald
  • MARTINEZ GONZALEZ, Sonia
Common Representative
  • JANSSEN PHARMACEUTICA N.V.
Priority Data
05112616.721.12.2005EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
(FR) NOUVEAUX DERIVES DE PYRAZINONE SUBSTITUEE A UTILISER LORS DE MALADIES MEDIEES PAR MCH-1
Abstract
(EN) The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-I activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereo chemically isomeric form thereof, an TV-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders ; obesity ; diabetes ; sexual disorders and neurological disorders.
(FR) L'invention concerne des dérivés de pyrazinone substituée par aryle et hétéroaryle présentant une activité d'hormone de concentration en mélanine (MCH) antagoniste, en particulier une activité de MCH-1 selon la formule générale (I), un sel d'addition d'acide ou de base, une forme stéréo-chimiquement isomère, une forme de N-oxyde ou un sel d'ammonium quaternaire de ceux-ci pharmaceutiquement acceptable, dont les paramètres sont définis dans la Revendication 1. L'invention concerne en outre la préparation de ces dérivés, les compositions les renfermant et leur utilisation comme médicament. Les composés selon l'invention servent à prévenir et/ou à traiter des troubles psychiatriques, notamment l'anxiété, les troubles de l'alimentation, les troubles de l'humeur, par exemple les troubles bipolaires et la dépression, les psychoses, par exemple la schizophrénie, et les troubles du sommeil; l'obésité; les diabètes; les troubles sexuels et les troubles neurologiques.
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