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1. WO2007069986 - NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS

Publication Number WO/2007/069986
Publication Date 21.06.2007
International Application No. PCT/SE2006/001426
International Filing Date 14.12.2006
IPC
C07D 498/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
08Bridged systems
A61K 31/5386 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5386spiro-condensed or forming part of bridged ring systems
A61P 9/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
CPC
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
C07D 498/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • BJÖRE, Annika [SE]/[SE] (UsOnly)
  • CLADINGBOEL, David [GB]/[GB] (UsOnly)
  • KAJANUS, Johan [SE]/[SE] (UsOnly)
  • OLSSON, Christina [SE]/[SE] (UsOnly)
  • PONTÉN, Fritiof [SE]/[SE] (UsOnly)
  • STRANDLUND, Gert [SE]/[SE] (UsOnly)
Inventors
  • BJÖRE, Annika
  • CLADINGBOEL, David
  • KAJANUS, Johan
  • OLSSON, Christina
  • PONTÉN, Fritiof
  • STRANDLUND, Gert
Agents
  • ASTRAZENECA AB
Priority Data
0502774-315.12.2005SE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS
(FR) NOUVEAUX COMPOSES POUR LE TRAITEMENT DES ARYTHMIES CARDIAQUES
Abstract
(EN) There is provided compounds of formula I, [Chemical formula should be inserted here. Please see paper copy] wherein R1 to R4, R41 to R46 and Z have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
(FR) La présente invention concerne des composés de formule I [Insérer la formule chimique ici. Voir la copie papier] dans laquelle R1 à R4, R41 à R46 et Z ont les définitions données dans la description, qui sont utiles dans la prophylaxie et dans le traitement des arythmies, en particulier des arythmies auriculaires et ventriculaires.
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