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1. (WO2007067946) DIAGNOSIS AND TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/067946 International Application No.: PCT/US2006/061727
Publication Date: 14.06.2007 International Filing Date: 07.12.2006
IPC:
C12Q 1/68 (2006.01) ,C07H 21/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 5th Floor Oakland, CA 94607-5200, US (AllExceptUS)
INSEL, Paul, A. [US/US]; US (UsOnly)
ZHANG, Lingzhi [CN/US]; US (UsOnly)
MURRAY, Fiona [GB/US]; US (UsOnly)
KANTER, Joan, R. [US/US]; US (UsOnly)
KIPPS, Thomas [US/US]; US (UsOnly)
RASSENTI, Laura [US/US]; US (UsOnly)
Inventors:
INSEL, Paul, A.; US
ZHANG, Lingzhi; US
MURRAY, Fiona; US
KANTER, Joan, R.; US
KIPPS, Thomas; US
RASSENTI, Laura; US
Agent:
WARREN, William, L. ; Sutherland Asbill & Brennan LLP 999 Peachtree Street, NE Atlanta, GA 30309, US
Priority Data:
60/748,25307.12.2005US
Title (EN) DIAGNOSIS AND TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
(FR) DIAGNOSTIC ET TRAITEMENT DE LA LEUCEMIE LYMPHOIDE CHRONIQUE (LLC)
Abstract:
(EN) The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided.
(FR) L'invention concerne des procédés diagnostiques et des trousses pour le diagnostic de la leucémie lymphoïde chronique (LLC) qui consistent à déterminer les taux d'expression d'isoformes de nucléotides cycliques phosphodiestérases (PDE) associées à la LLC, en particulier PDE7B et/ou PDE3B, et le rapport entre l'expression d'ARNm de PDE7B et celle de PDE3B. L'invention établit que les lymphocytes LLC expriment uniformément des taux élevés de PDE7B et de faibles taux de PDE3B par rapport aux lymphocytes normaux. L'invention concerne aussi une méthode de traitement de la LLC et une composition pharmaceutique correspondante, qui comprend un ou plusieurs agents thérapeutiques pouvant moduler l'expression ou les taux d'activité d'isoformes de PDE associées à la LLC, et/ou inverser le rapport des taux d'expression d'ARNm de PDE7B/PDE3B.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20090131353