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1. (WO2007064993) BICYCLIC PROTEIN KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/064993 International Application No.: PCT/US2006/046226
Publication Date: 07.06.2007 International Filing Date: 04.12.2006
IPC:
C07D 487/04 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/00 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/4985 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
Applicants:
OSI PHARMACEUTICALS, INC. [US/US]; 41 Pinelawn Road Melville, NY 11747, US (AllExceptUS)
CREW, Andrew, Philip [GB/US]; US (UsOnly)
DONG, Han-Qing [CN/US]; US (UsOnly)
MULVIHILL, Mark, Joseph [US/US]; US (UsOnly)
WERNER, Douglas, S. [US/US]; US (UsOnly)
KADALBAJOO, Mridula [IN/US]; US (UsOnly)
LAUFER, Radoslaw [CA/CA]; CA (UsOnly)
Inventors:
CREW, Andrew, Philip; US
DONG, Han-Qing; US
MULVIHILL, Mark, Joseph; US
WERNER, Douglas, S.; US
KADALBAJOO, Mridula; US
LAUFER, Radoslaw; CA
Agent:
NGUYEN, Kim, T.; OSI PHARMACEUTICALS, INC. 41 Pinelawn Road Melville, NY 11747 , US
Priority Data:
60/741,58802.12.2005US
Title (EN) BICYCLIC PROTEIN KINASE INHIBITORS
(FR) INHIBITEURS BICYCLIQUES DE LA PROTEINE KINASE
Abstract:
(EN) Compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit protein kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
(FR) La présente invention concerne des composés de formule (I), dans laquelle X1, X2, X3, X4, X5, X6, X7, R1 et Q1 sont tels que définis ici, et leurs sels pharmaceutiquement acceptables. Lesdits composés inhibent les enzymes protéine kinase et ils sont utiles pour le traitement et/ou la prévention des maladies hyperprolifératives telles que le cancer, l'inflammation, le psoriasis, l'allergie/l'asthme, les maladies et les états du système immunitaire et les maladies et les états du système nerveux central.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1957496ES2395835