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1. WO2007055243 - ASBESTOS DETECTION METHOD, ASBESTOS DETECTION AGENT, ASBESTOS DETECTION KIT AND METHOD OF SCREENING CANDIDATE FOR DRUG AIMING AT PREVENTING OR TREATING DISEASE CAUSED OR WORSENED BY ASBESTOS

Publication Number WO/2007/055243
Publication Date 18.05.2007
International Application No. PCT/JP2006/322279
International Filing Date 08.11.2006
IPC
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/566 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
CPC
G01N 2500/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
G01N 33/5308
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
5308for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
Applicants
  • 国立大学法人広島大学 National University of Corporation Hiroshima University [JP]/[JP] (AllExceptUS)
  • 黒田 章夫 KURODA, Akio (UsOnly)
  • 野村 和孝 NOMURA, Kazutaka (UsOnly)
Inventors
  • 黒田 章夫 KURODA, Akio
  • 野村 和孝 NOMURA, Kazutaka
Agents
  • 特許業務法人原謙三国際特許事務所 HARAKENZO WORLD PATENT & TRADEMARK
Priority Data
2005-32650210.11.2005JP
2006-00506112.01.2006JP
2006-13567415.05.2006JP
2006-20398326.07.2006JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) ASBESTOS DETECTION METHOD, ASBESTOS DETECTION AGENT, ASBESTOS DETECTION KIT AND METHOD OF SCREENING CANDIDATE FOR DRUG AIMING AT PREVENTING OR TREATING DISEASE CAUSED OR WORSENED BY ASBESTOS
(FR) PROCEDE DE DETECTION DE L'AMIANTE, AGENT DE DETECTION DE L'AMIANTE, TROUSSE DE DETECTION DE L'AMIANTE ET PROCEDE DE CRIBLAGE D'UN AGENT CANDIDAT POUR LA MISE AU POINT D'UN MEDICAMENT DESTINE A LA PREVENTION OU AU TRAITEMENT DE MALADIES CAUSEES OU AGGRAVEES PAR L'AMIANTE
(JA) 石綿検出方法、石綿検出剤および石綿検出キット、並びに、石綿が病因または増悪因子となる疾病を予防または治療する薬剤候補物質のスクリーニング方法
Abstract
(EN) It is intended to provide a method of quickly and conveniently detecting asbestos, and a method of screening a candidate for a drug aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. Asbestos in a sample can be quickly and conveniently detected by finding a protein capable of binding specifically to asbestos, allowing this protein or a fused protein composed of this protein with a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fused protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for a drug aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.
(FR) L'invention concerne un procédé permettant de détecter rapidement et sans inconvénient la présence d'amiante, ainsi qu'un procédé de criblage d'un agent candidat pour la mise au point d'un médicament destiné à la prévention ou au traitement de maladies causées ou aggravées par l'amiante. Ce procédé permet de détecter rapidement et sans inconvénient la présence d'amiante dans un échantillon. Il consiste à trouver une protéine capable de se fixer de manière spécifique sur l'amiante, à permettre à cette protéine ou à une protéine hybride composée de cette protéine et d'une protéine rapporteuse de se fixer sur l'amiante dans l'échantillon, puis à détecter la protéine ou la protéine hybride qui s'est fixée sur l'amiante. L'invention concerne également une substance qui inhibe la fixation de l'actine sur l'amiante. Il s'est avéré que cette substance agit comme une protéine capable de se fixer de manière spécifique sur l'amiante. Ainsi, cette substance constitue un agent candidat pour la mise au point d'un médicament destiné à la prévention ou au traitement de maladies causées ou aggravées par l'amiante.
(JA)  迅速・簡便な石綿検出方法および石綿が病因または増悪因子となる疾病を予防または治療する薬剤の候補物質をスクリーニングする方法を提供する。  石綿と特異的に結合し得るタンパク質を見出し、当該タンパク質または当該タンパク質とレポータータンパク質との融合タンパク質を試料中の石綿と結合させ、石綿と結合した当該タンパク質または融合タンパク質を検出することにより、試料中の石綿を迅速・簡便に検出できる。また、石綿と特異的に結合し得るタンパク質として見出されたアクチンと石綿との結合を阻害する物質は、石綿が病因または増悪因子となる疾病を予防または治療する薬剤の候補物質となる。
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