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1. WO2007054693 - USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS

Publication Number WO/2007/054693
Publication Date 18.05.2007
International Application No. PCT/GB2006/004178
International Filing Date 08.11.2006
IPC
A61K 31/4439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A01N 43/90
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A61K 31/43
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/4706
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A61K 31/4709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines and containing further heterocyclic rings
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
Applicants
  • HELPERBY THERAPEUTICS LIMITED [GB]/[GB] (AllExceptUS)
  • BECK, Petra, Helga [DE]/[GB] (UsOnly)
  • BROWN, Marc, Barry [GB]/[GB] (UsOnly)
  • CLARK, David, Edward [GB]/[GB] (UsOnly)
  • COATES, Anthony [GB]/[GB] (UsOnly)
  • DYKE, Hazel, Joan [GB]/[GB] (UsOnly)
  • HU, Yanmin [GB]/[GB] (UsOnly)
  • LONDESBROUGH, Derek, John [GB]/[GB] (UsOnly)
  • MILLS, Keith [GB]/[GB] (UsOnly)
  • PALLIN, Thomas, David [GB]/[GB] (UsOnly)
  • REID, Gary, Patrick [GB]/[GB] (UsOnly)
  • STODDART, Gerlinda [GB]/[GB] (UsOnly)
Inventors
  • BECK, Petra, Helga
  • BROWN, Marc, Barry
  • CLARK, David, Edward
  • COATES, Anthony
  • DYKE, Hazel, Joan
  • HU, Yanmin
  • LONDESBROUGH, Derek, John
  • MILLS, Keith
  • PALLIN, Thomas, David
  • REID, Gary, Patrick
  • STODDART, Gerlinda
Agents
  • SNODIN, Michael, D.
Priority Data
0522715.208.11.2005GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
(FR) UTILISATION DE DÉRIVÉS DE PYRROLOQUINOLINE POUR L'ÉLIMINATION DE MICRO-ORGANISMES PERSISTANTS AU NIVEAU CLINIQUE
Abstract
(EN) There is provided the use of compounds of formula (I), wherein R1 R2 R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula (I) for treating microbial infections, as well as certain compounds of formula (I) per se.
(FR) La présente invention porte sur l'utilisation de composés de formule (I), où R1 R2 R3 et X ont les valeurs données dans la description, dans l'élaboration d'un médicament pour l'élimination de micro-organismes persistants au niveau clinique. La présente invention porte également sur l'utilisation des composés de formule (I) dans le traitement d'infections microbiennes, ainsi que sur certains composés de formule (I) en eux-mêmes.
Related patent documents
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