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1. WO2007047646 - SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS

Publication Number WO/2007/047646
Publication Date 26.04.2007
International Application No. PCT/US2006/040507
International Filing Date 13.10.2006
IPC
A61K 31/554 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
554having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
A61K 9/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
26Discrete particles in supporting matrix
CPC
C07D 209/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
C07D 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
Applicants
  • JANSSEN PHARMACEUTICA, N.V. [BE]/[BE] (AllExceptUS)
  • CONNOLLY, Peter, J. [US]/[US] (UsOnly)
  • EMANUEL, Stuart, L. [US]/[US] (UsOnly)
  • HUGHES, Terry, V. [US]/[US] (UsOnly)
  • RUGG, Catherine, A. [AU]/[US] (UsOnly)
Inventors
  • CONNOLLY, Peter, J.
  • EMANUEL, Stuart, L.
  • HUGHES, Terry, V.
  • RUGG, Catherine, A.
Agents
  • JOHNSON, Philip, S.
Priority Data
60/727,15514.10.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS
(FR) DIHYDROISOINDOLONES SUBSTITUÉES POUVANT ÊTRE EMPLOYÉES DANS LE TRAITEMENT DE TROUBLES DES KINASES
Abstract
(EN)
The present invention is directed to novel substituted dihydro-isoindolone compounds of formula (I): and forms thereof, wherein Ring A, X3, R1, R2, R3, R4 and R6 are as herein defined, and their synthesis and use as protein kinase inhibitors and interactions thereof.
(FR)
La présente invention a pour objet de nouveaux dérivés substitués de dihydroisoindolone de formule (I) : ainsi que diverses formes desdits dérivés, le Cycle A et les groupements X3, R1, R2, R3, R4 et R6 étant tels que définis dans la description, ainsi que leur synthèse et leur emploi en tant qu'inhibiteurs de protéine kinase et leurs interactions.
Also published as
EP6826092
Latest bibliographic data on file with the International Bureau