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1. (WO2007046456) AGENT FOR PREVENTING OR TREATING PANCREAS CANCER, OVARY CANCER OR LIVER CANCER CONTAINING NOVEL WATER-SOLUBLE PRODRUG
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/046456 International Application No.: PCT/JP2006/320814
Publication Date: 26.04.2007 International Filing Date: 19.10.2006
IPC:
A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01) ,C07D 491/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
22
in which the condensed system contains four or more hetero rings
Applicants:
梅田 勲 UMEDA, Isao [JP/JP]; JP (UsOnly)
大和田 潤 OHWADA, Jun [JP/JP]; JP (UsOnly)
小澤 佐和子 OZAWA, Sawako [JP/JP]; JP (UsOnly)
遠藤 美香 ENDO, Mika [JP/JP]; JP (UsOnly)
浦 雅子 URA, Masako [JP/JP]; JP (UsOnly)
中外製薬株式会社 CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 〒1158543 東京都北区浮間5丁目5番1号 Tokyo 5-1, Ukima 5-chome, Kita-ku, Tokyo 1158543, JP (AllExceptUS)
Inventors:
梅田 勲 UMEDA, Isao; JP
大和田 潤 OHWADA, Jun; JP
小澤 佐和子 OZAWA, Sawako; JP
遠藤 美香 ENDO, Mika; JP
浦 雅子 URA, Masako; JP
Agent:
清水 初志 SHIMIZU, Hatsushi; 〒3000847 茨城県土浦市卸町1-1-1 関鉄つくばビル6階 Ibaraki Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 3000847, JP
Priority Data:
2005-30420819.10.2005JP
Title (EN) AGENT FOR PREVENTING OR TREATING PANCREAS CANCER, OVARY CANCER OR LIVER CANCER CONTAINING NOVEL WATER-SOLUBLE PRODRUG
(FR) AGENT DE PREVENTION OU DE TRAITEMENT DU CANCER DU PANCREAS, DU CANCER DE L'OVAIRE OU DU CANCER DU FOIE CONTENANT UN PROMEDICAMENT INNOVANT SOLUBLE DANS L'EAU
(JA) 新規水溶性プロドラッグを含有する、膵臓癌、卵巣癌または肝臓癌の予防または治療剤
Abstract:
(EN) An agent for preventing or treating pancreas cancer, ovary cancer or liver cancer which contains a water-soluble prodrug represented by the following general formula (1): wherein R1 represents hydrogen or C1-6 alkyl; W represents a divalent group including a tertiary amino group or a divalent group including a sulfonyl group; and Y represents an alcoholic hydroxyl group represented by Y-OH wherein Y-OH is a camptotecin, taxane or an anticancer nucleotide; or a pharmaceutically acceptable salt thereof or a hydrate or a solvate of the same.
(FR) La présente invention concerne un agent de prévention ou de traitement du cancer du pancréas, du cancer de l'ovaire ou du cancer du foie qui contient un promédicament soluble dans l'eau représenté par la formule générale (1) : dans laquelle R1 représente un hydrogène ou un C1-6 alkyle ; W représente un groupe divalent incluant un groupe amine tertiaire ou un groupe divalent incluant un groupe sulfonyle ; et Y représente un groupe hydroxyle alcoolique représenté par Y-OH dans lequel Y-OH est une camptotécine, un taxane ou un nucléotide anticancéreux ; ou un de leurs sels pharmaceutiquement acceptables ou un de leurs hydrates ou solvates.
(JA)  本発明に係る膵臓癌、卵巣癌または肝臓癌の予防または治療剤は、下記一般式(1) (式中、R1は、水素原子またはC1-C6アルキル基を示し;Wは、3級アミノ基を含む2価の基またはスルホニル基を含む2価の基を示し;Yは、Y-OHで表されるアルコール性水酸基を有する化合物の残基であって、該Y-OHはカンプトテシン類、タキサン類または抗癌ヌクレオチド類である。)で表される水溶性プロドラッグ、もしくはその医薬的に許容し得る塩、またはこれらの水和物もしくは溶媒和物を含有する。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)