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1. WO2007045339 - IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA

Publication Number WO/2007/045339
Publication Date 26.04.2007
International Application No. PCT/EP2006/009500
International Filing Date 30.09.2006
IPC
C07D 413/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 417/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/435 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
A61K 31/41 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61P 7/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
16Central respiratory analeptics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • SANOFI-AVENTIS [FR]/[FR] (AllExceptUS)
  • KALLUS, Christopher [DE]/[DE] (UsOnly)
  • HEITSCH, Holger [DE]/[DE] (UsOnly)
  • WEHNER, Volkmar [DE]/[DE] (UsOnly)
Inventors
  • KALLUS, Christopher
  • HEITSCH, Holger
  • WEHNER, Volkmar
Priority Data
10 2005 049 385.815.10.2005DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) IMIDAZOLDERIVATE ALS INHIBITOREN VON TAFI-A
(EN) IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA
(FR) DERIVES IMIDAZOLE SERVANT D'INHIBITEURS DE TAFI-A
Abstract
(DE)
Die Erfindung betrifft Verbindungen der Formel (I) die Inhibitoren von aktivierter Thrombin-aktivierbarer Fibrinolyse Inhibitor sind. Die Verbindungen der Formel (I) eignen sich zur Herstellung von Arzneimitteln zur Prophylaxe, Sekundärprevention und Therapie von Erkrankungen, die mit Thrombosen, Embolien, Hyperkoagulabilität oder fibrotischen Veränderungen einhergehen.
(EN)
The invention relates to compounds of formula (I), which act as inhibitors of activated thrombin activatable fibrinolysis inhibitors (TAFI). The compounds of formula (I) are suitable for the production of medicaments for the prophylaxis, secondary prevention and treatment of diseases that are associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
(FR)
L'invention concerne les composés représentés par la formule (I) étant des inhibiteurs de fibrinolyse activable par thrombine, activée. Les composés de la formule (I) servent à la fabrication de médicaments destinés à la prophylaxie, à la prévention secondaire et à la thérapie de maladies asociées à des thromboses, à des embolies, à l'hypercoagulabilité ou à des modifications fibrotiques.
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