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1. WO2007044323 - FUSION PROTEINS FOR BLOOD-BRAIN BARRIER DELIVERY

Publication Number WO/2007/044323
Publication Date 19.04.2007
International Application No. PCT/US2006/038587
International Filing Date 28.09.2006
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 21/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
04for myasthenia gravis
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
Applicants
  • ARMAGEN TECHNOLOGIES, INC. [US]/[US] (AllExceptUS)
  • PARDRIDGE, William, M. [US]/[US] (UsOnly)
  • BOADO, Ruben, J. [AR]/[US] (UsOnly)
Inventors
  • PARDRIDGE, William, M.
  • BOADO, Ruben, J.
Agents
  • WITT, Eric
Priority Data
11/245,54607.10.2005US
11/245,71007.10.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSION PROTEINS FOR BLOOD-BRAIN BARRIER DELIVERY
(FR) PROTEINES DE FUSION POUR ADMINISTRATION A TRAVERS LA BARRIERE HEMATO-ENCEPHALIQUE
Abstract
(EN)
The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain substantially intact. The agents are transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems. In some embodiments the agents are therapeutic, diagnostic, or research agents.
(FR)
Cette invention concerne des compositions, des méthodes et des kits permettant d'accroître le transport d'agents à travers la barrière hémato-encéphalique quasiment sans perte substantielle d'activité de ces agents une fois la barrière traversée. Lesdits agents sont transportés au travers le la barrière hépato-encéphalique via un ou plusieurs systèmes de transport induits par des récepteurs endogènes. Dans certains modes de réalisation, les agents sont utilisés à des fins thérapeutique, diagnostique ou de recherche.
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