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1. WO2007043202 - STABLE NOVEL NITRON COMPOUND AND USE THEREOF

Publication Number WO/2007/043202
Publication Date 19.04.2007
International Application No. PCT/JP2006/306588
International Filing Date 23.03.2006
IPC
C07F 9/6574 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6571having phosphorus and oxygen atoms as the only ring hetero atoms
6574Esters of oxyacids of phosphorus
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
CPC
A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
C07F 9/657181
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6571having phosphorus and oxygen atoms as the only ring hetero atoms
657163the ring phosphorus atom being bound to at least one carbon atom
657181the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Applicants
  • 三國製薬工業株式会社 MIKUNI PHARMACEUTICAL INDUSTRIAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • ヘテロリサーチ有限会社 HETERO RESEARCH CO., LTD. [JP]/[JP] (AllExceptUS)
  • 上林 將人 KAMIBAYASHI, Masato [JP]/[JP] (UsOnly)
  • 亀田 裕昭 KAMEDA, Hiroaki [JP]/[JP] (UsOnly)
  • 岡田 泰一 OKADA, Taiichi [JP]/[JP] (UsOnly)
Inventors
  • 上林 將人 KAMIBAYASHI, Masato
  • 亀田 裕昭 KAMEDA, Hiroaki
  • 岡田 泰一 OKADA, Taiichi
Agents
  • 水野 昭宣 MIZUNO, Akinobu
Priority Data
2005-29421106.10.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) STABLE NOVEL NITRON COMPOUND AND USE THEREOF
(FR) NOUVEAU COMPOSE NITRO STABLE ET SON UTILISATION
(JA) 安定な新規ニトロン化合物とその用途
Abstract
(EN)
A novel compound useful as a radical scavenger for use in electron spin resonance measurement, etc. There are provided novel nitron compounds and salts thereof, the nitron compounds represented by the general formula: (1) wherein each of R1 and R2 is a hydrogen atom, C1-C4 lower alkyl, carboxyl, alkoxycarbonyl or carbamoyl, and each of R3 and R4 is a hydrogen atom or C1-C4 lower alkyl. Further, there are provided radical scavengers and diagnostic drugs comprising compounds of the general formula (1) or salts thereof.
(FR)
L’invention concerne un nouveau composé utile en tant qu’accepteur de radicaux, destiné à une utilisation pour des mesures de résonance paramagnétique électronique, etc. L’invention concerne donc de nouveaux composés nitro et leurs sels, lesdits composés nitro étant représentés par la formule générale : (1) dans laquelle chacun des R1 et R2 représente un atome d’hydrogène, un alkyle inférieur en C1-C4, un carboxyle, un alcoxycarbonyle ou un carbamoyle, et chacun des R3 et R4 représente un atome d’hydrogène ou un alkyle inférieur en C1-C4. L’invention concerne également des accepteurs de radicaux et des médicaments de diagnostic comprenant des composés de formule générale (1) ou des sels de ces composés.
(JA)
not available
Also published as
EP6730536
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