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1. (WO2007041481) RAPID ACTING AND PROLONGED ACTING INSULIN PREPARATIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/041481 International Application No.: PCT/US2006/038410
Publication Date: 12.04.2007 International Filing Date: 29.09.2006
Chapter 2 Demand Filed: 27.07.2007
IPC:
A61K 38/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
Applicants:
BIODEL, INC. [US/US]; 6 Christopher Columbus Avenue Danbury, CT 06810, US (AllExceptUS)
STEINER, Solomon, S. [US/US]; US (UsOnly)
POHL, Roderike [US/US]; US (UsOnly)
Inventors:
STEINER, Solomon, S.; US
POHL, Roderike; US
Agent:
PABST, Patrea, L. ; Pabst Patent Group LLP 1201 Peachtree Street Suite 1200 Atlanta, GA 30361, US
Priority Data:
60/721,69829.09.2005US
Title (EN) RAPID ACTING AND PROLONGED ACTING INSULIN PREPARATIONS
(FR) PREPARATIONS D'INSULINE A ACTION RAPIDE ET PROLONGEE
Abstract:
(EN) It has been discovered that by combining a chelator such as ethylenediaminetetraacetic acid with an acidifier such as citric acid, that the insulin is absorbed much more rapidly than in the absence of the chelator and acidifier. It has also been determined that by combining insulin with a chelator and acidifier, with a commercially available rapid, intermediate or long lasting insulin such as glargine, one can increase and/or prolong the bioavailability of the insulin mixture. The formulations are suitable for administration by injection or to a mucosal surface such as the pulmonary or oral regions, although subcutaneous injection is preferred.
(FR) L'on a découvert que, en combinant un chélateur, tel que l'acide éthylène-diamine-tétra-acétique, avec un acidifiant, tel que l'acide citrique, l'insuline est absorbée beaucoup plus rapidement qu'en l'absence du chélateur et de l'acidifiant. Il a également été établi que, en combinant une insuline comprenant un chélateur et un acidifiant avec une insuline du commerce présentant une action rapide, intermédiaire ou prolongée, telle que la glargine, on peut augmenter et/ou prolonger la biodisponibilité du mélange d'insulines. Les préparations obtenues peuvent être administrées par injection ou sur une surface de muqueuse, telle que les régions pulmonaires ou buccales, bien qu'une injection sous-cutanée soit préférable.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)