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1. WO2007037513 - ARYL-SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

Publication Number WO/2007/037513
Publication Date 05.04.2007
International Application No. PCT/JP2006/319912
International Filing Date 28.09.2006
IPC
C07D 207/335 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
33with substituted hydrocarbon radicals, directly attached to ring carbon atoms
335Radicals substituted by nitrogen atoms not forming part of a nitro radical
A61K 31/402 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4021-aryl-substituted, e.g. piretanide
A61K 31/415 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
A61K 31/4155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
4155not condensed and containing further heterocyclic rings
A61K 31/417 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
417Imidazole-alkylamines, e.g. histamine, phentolamine
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
CPC
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • 萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 岡本 収 OKAMOTO, Osamu [JP]/[JP] (UsOnly)
  • 小林 健介 KOBAYASHI, Kensuke [JP]/[JP] (UsOnly)
  • 伊藤 裕勝 ITO, Hirokatsu [JP]/[JP] (UsOnly)
  • 辻田 智大 TSUJITA, Tomohiro [JP]/[JP] (UsOnly)
  • 尾崎 諭司 OZAKI, Satoshi [JP]/[JP] (UsOnly)
  • 太田 尚 OHTA, Hisashi [JP]/[JP] (UsOnly)
Inventors
  • 岡本 収 OKAMOTO, Osamu
  • 小林 健介 KOBAYASHI, Kensuke
  • 伊藤 裕勝 ITO, Hirokatsu
  • 辻田 智大 TSUJITA, Tomohiro
  • 尾崎 諭司 OZAKI, Satoshi
  • 太田 尚 OHTA, Hisashi
Common Representative
  • 萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD.
Priority Data
2005-28854530.09.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ARYL-SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE AZOTÉ SUBSTITUÉ PAR UN GROUPE ARYLE
(JA) アリール置換含窒素複素環化合物
Abstract
(EN)
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as a nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [In the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted by a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
(FR)
La présente invention concerne un composé hétérocyclique azoté substitué par un groupe aryle représenté par la formule (I) ci-dessous ou un sel pharmaceutiquement acceptable de celui-ci. Ce composé sert d'antagoniste de récepteur de nociceptine et est utile comme agent pharmaceutique pour traiter des maladies liées à un récepteur de nociceptine. (I) [Dans la formule, A1, A2 et A3 représentent indépendamment un atome de carbone ou un atome d'azote, et un ou deux parmi A1, A2 et A3 représentent un atome de carbone ; R1 représente un groupe alkyle inférieur ou analogues ; R2 représente un groupe phényle qui peut être substitué par un atome d'halogène ou analogues ; R3 représente un atome d'hydrogène, un groupe alkyle inférieur ou analogues ; et R4 représente un groupe alkyle inférieur ou analogues.]
(JA)
 式(I)[式中、A、A及びAは、同一又は異なって、炭素原子又は窒素原子を表し、但し、A、A及びAのうちいずれか1又は2つが炭素原子であり、Rは、低級アルキル基等を表し、Rは、場合によりハロゲン原子で置換されていてもよいフェニル基等を表し、Rは、水素原子、低級アルキル基等を表し、Rは、低級アルキル基等を表す。]で表されるアリール置換含窒素複素環化合物又は薬学的に許容されうるその塩を提供する。この化合物は、ノシセプチン受容体拮抗剤として作用し、ノシセプチン受容体が関連する疾患の医薬として有用である。
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