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1. WO2007035957 - METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS

Publication Number WO/2007/035957
Publication Date 29.03.2007
International Application No. PCT/US2006/037378
International Filing Date 25.09.2006
IPC
A61K 31/155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
A61K 31/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
CPC
A61K 31/13
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
A61K 31/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • PATHOLOGICA, LLC. [US]/[US] (AllExceptUS)
  • MCGRATH, Michael, S. [US]/[US] (UsOnly)
  • HADLOCK, Kenneth, G. [US]/[US] (UsOnly)
Inventors
  • MCGRATH, Michael, S.
  • HADLOCK, Kenneth, G.
Agents
  • WU, Nan
Priority Data
60/719,57323.09.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS
(FR) METHODES DE TRAITEMENT D'INFECTIONS VIRALES AU MOYEN D'ANALOGUES DE POLYAMINE
Abstract
(EN)
Methods for treating viral infections using polyamine analogs, including mitoguazone (MGBG), are provided. In these methods, polyamine analogs destroy macrophages that act as viral reservoirs, facilitating the destruction of the viruses that dwell within the macrophages. Examples of viral infections that may be treated with the present methods include, but are not limited to, infections from human immunodeficiency viruses. These methods differ from previous methods of treatment using polyamine analogs, wherein the polyamine analogs were administered only as anti-tumor agents.
(FR)
Méthodes de traitement d'infections virales au moyen d'analogues de polyamine, dont le mitoguazone (MGBG). Ces méthodes consistent à utiliser des analogues de polyamine pour détruire des macrophages qui agissent comme des réservoirs de virus, ce qui facilite la destruction des virus résidant dans les macrophages. Les méthodes de l'invention permettent de traiter notamment, mais pas uniquement, des infections transmises par des virus de l'immuno-déficience humaine. Ces méthodes différent des méthodes de traitement au moyen d'analogues de polyamine utilisées jusqu'alors dans la mesure ou lesdits analogues n'étaient administrés que comme agents anti-tumoraux.
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