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1. (WO2007030691) ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING PICORNAVIRUS INFECTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/030691 International Application No.: PCT/US2006/034986
Publication Date: 15.03.2007 International Filing Date: 08.09.2006
IPC:
A61K 31/70 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
AVI BIOPHARMA, INC. [US/US]; 4575 S.W. Research Way, Suite 200 Corvallis, OR 97333, US (AllExceptUS)
STEIN, David, A. [US/US]; US (UsOnly)
BESTWICK, Richard, K. [US/US]; US (UsOnly)
IVERSEN, Patrick, L. [US/US]; US (UsOnly)
WELLER, Dwight, D. [US/US]; US (UsOnly)
Inventors:
STEIN, David, A.; US
BESTWICK, Richard, K.; US
IVERSEN, Patrick, L.; US
WELLER, Dwight, D.; US
Agent:
FRESCHI, Gina, C. ; PERKINS COIE LLP P.O. Box 2168 Menlo Park, CA 94026, US
Priority Data:
60/716,00108.09.2005US
60/800,14511.05.2006US
Title (EN) ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING PICORNAVIRUS INFECTION
(FR) COMPOSE ANTISENS ANTIVIRAL ET PROCEDE DE TRAITEMENT D'INFECTION PICORNAVIRALE
Abstract:
(EN) The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 51 untranslated region identified by SEQ ID NO:7.
(FR) L'invention concerne des composés antisens antiviraux et leurs procédés d'utilisation et de production au niveau de l'inhibition de la croissance des virus de la famille Picornaviridae et du traitement d'une infection virale. Ces composés sont particulièrement utiles pour traiter l'infection de l'Enterovirus et/ou du Rhinovirus chez un mammifère. Les composés antisens antiviraux sont sensiblement neutres, des oligonucléotides morpholino ayant une séquence de 12-40 sous-unités, comportant au moins 12 sous-unités ayant une séquence cible complémentaire d'une zone associée à des séquences ARN virales à l'intérieur d'une zone nucléotidique de 32 de la zone non traduite 5' identifiée par SEQ ID NO:7.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)