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1. WO2007027742 - SMALL MOLECULE INTEGRIN &agr;2&bgr;l/GPIa-IIa ANTAGONISTS

Publication Number WO/2007/027742
Publication Date 08.03.2007
International Application No. PCT/US2006/033819
International Filing Date 29.08.2006
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/06086
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06086with the first amino acid being basic
C07K 5/06113
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06104with the first amino acid being acidic
06113Asp- or Asn-amino acid
C07K 5/06191
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06191containing heteroatoms different from O, S, or N
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US] (AllExceptUS)
  • CHOI, Sungwook [KR]/[US] (UsOnly)
  • SNYDER, Seth, E. [US]/[US] (UsOnly)
  • DEGRADO, William, F. [US]/[US] (UsOnly)
  • BENNETT, Joel, S. [US]/[US] (UsOnly)
Inventors
  • CHOI, Sungwook
  • SNYDER, Seth, E.
  • DEGRADO, William, F.
  • BENNETT, Joel, S.
Agents
  • CALDWELL, John, W.
Priority Data
60/712,77531.08.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SMALL MOLECULE INTEGRIN &agr;2&bgr;l/GPIa-IIa ANTAGONISTS
(FR) ANTAGONISTES DE L'INTEGRINE $G(A)2$G(B)1/GPIA-IIA A PETITES MOLECULES
Abstract
(EN)
Novel compounds inhibiting the integrin &agr;2&bgr;l /GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic uses. The compounds disclosed are useful, inter alia, as inhibitors of integrin &agr;2&bgr;l/GPIa-IIa-mediated activity.
(FR)
Cette invention concerne de nouveaux composés qui inhibent le récepteur de l'intégrine $g(a)2$g(b)1/GPIa-IIa. Cette invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que des méthodes d'utilisations thérapeutiques de celles-ci. Ces composés sont utilisés, notamment, comme inhibiteurs de l'activité induite par l'intégrine $g(a)2$g(b)1/GPIa-IIa.
Also published as
EP6790092
EP06790092
Latest bibliographic data on file with the International Bureau