US2006032512 METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS

1. (WO2007022477) METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2007/022477		International Application No.:		PCT/US2006/032512
Publication Date:		22.02.2007		International Filing Date:		17.08.2006

IPC:

A61K 39/00 (2006.01)

Applicants:

MULTICELL IMMUNOTHERAPEUTICS, INC. [US/US]; 9710 Scranton Road, Suite 170, San Diego, CA 92121 (US) (For All Designated States Except US).
WANG, Lilin [CN/US]; (US) (For US Only).
SMITH, Dan [US/US]; (US) (For US Only).
PHILLIPS, Bill [US/US]; (US) (For US Only).
BOT, Adrian [RO/US]; (US) (For US Only)

Inventors:

WANG, Lilin; (US).
SMITH, Dan; (US).
PHILLIPS, Bill; (US).
BOT, Adrian; (US)

Agent:

FARBER, Michael, B.; CATALYST LAW GROUP, APC, 9710 Scranton Road, Suite 170, San Diego, CA 92121 (US)

Priority Data:

60/708,980

17.08.2005

Title

(EN) METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS
(FR) MÉTHODES ET COMPOSITIONS POUR PRODUIRE ET CONTRÔLER LE PROFIL EFFECTEUR DE LYMPHOCYTES T PAR CHARGEMENT ET ACTIVATION SIMULTANÉS DE SOUS-ENSEMBLES SÉLECTIONNÉS DE CELLULES PRÉSENTATRICES D'ANTIGÈNE

Abstract:

(EN)The present invention is directed to novel compositions and methods and their use in treating an autoimmune disorder or achieving tolerance to an antigen. More specifically, the present invention is directed to human immunoglobulin constructs for loading a delivered T cell epitope on to the surface of an antigen presenting cell for achieving tolerance to that delivered T cell epitope. The present invention may be applied to any T cell epitope mediated autoimmune disorder.
(FR)La présente invention a pour objet de nouvelles compositions et méthodes ainsi que leur utilisation pour traiter un trouble auto-immun ou pour obtenir la tolérance vis-à-vis d'un antigène. Plus spécifiquement, la présente invention concerne des constructions d'immunoglobulines humaines pour charger un épitope livré de lymphocyte T à la surface d'une cellule présentatrice d'antigène afin d'obtenir la tolérance vis-à-vis de cet épitope livré de lymphocyte T. La présente invention peut être appliquée à tout trouble auto-immun assisté par épitope de lymphocyte T.

Designated States:

AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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