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1. (WO2007022416) SINGLE CHAIN ANTIBODIES AGAINST BETA-AMYLOID PEPTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/022416    International Application No.:    PCT/US2006/032319
Publication Date: 22.02.2007 International Filing Date: 18.08.2006
IPC:
C07K 16/18 (2006.01), C12N 15/13 (2006.01), C12N 15/63 (2006.01), C12N 5/10 (2006.01), A61K 39/395 (2006.01), A61P 25/28 (2006.01)
Applicants: RAMOT AT TEL AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296, 61392 Tel Aviv (IL) (For All Designated States Except US).
SOLOMON, Beka [IL/IL]; (IL) (For US Only).
COHEN-KUPIEC, Rachel [IL/IL]; (IL) (For US Only).
GERAGHTY, Erin [US/US]; (US) (SD only)
Inventors: SOLOMON, Beka; (IL).
COHEN-KUPIEC, Rachel; (IL)
Agent: BROWDY AND NEIMARK, P.L.L.C.; 624 Ninth Street N.w., Suite 300, Washington, District Of Columbia 20001-5303 (US)
Priority Data:
60/709,102 18.08.2005 US
Title (EN) SINGLE CHAIN ANTIBODIES AGAINST BETA-AMYLOID PEPTIDE
(FR) ANTICORPS MONOCATENAIRES DIRIGES CONTRE LE PEPTIDE $G(B)-AMYLOIDE
Abstract: front page image
(EN)Anti-AßP scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-Aßp scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-AßP scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.
(FR)L'invention concerne la production d'anticorps scFv anti-A$g(b)P et à domaine unique. Ces anticorps, lorsqu'ils sont présentés sur un phage filamenteux ou comme molécules de protéine soluble stabilisées par la protéine de liaison au maltose, empêchent la formation de fibrilles d'A$g(b)p 1-40 et désagrègent les fibrilles d'A$g(b)p 1-40 produits in vitro. De plus, les anticorps scFv anti-A$g(b)p colorent les plaques séniles amyloïdes sur des coupes de souris transgéniques. Les anticorps scFv anti-A$g(b)P et à domaine unique peuvent servir à inhiber ou à traiter la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)