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Machine translation
1. (WO2007022165) FACTOR XA INHIBITOR INCLUSION COMPLEX WITH CYCLODEXTRIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/022165    International Application No.:    PCT/US2006/031801
Publication Date: 22.02.2007 International Filing Date: 16.08.2006
Chapter 2 Demand Filed:    30.08.2007    
IPC:
A61K 47/48 (2006.01), A61K 9/00 (2006.01), A61P 7/02 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000, Route 206 And ProvinceLine Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
NASSAR, Munir N. [US/US]; (US) (For US Only).
GOGATE, Uday Shankar [US/US]; (US) (For US Only).
MALLOY, Timothy M. [US/US]; (US) (For US Only)
Inventors: NASSAR, Munir N.; (US).
GOGATE, Uday Shankar; (US).
MALLOY, Timothy M.; (US)
Agent: SUN, Jing G.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/709,077 17.08.2005 US
11/464,519 15.08.2006 US
Title (EN) FACTOR XA INHIBITOR INCLUSION COMPLEX WITH CYCLODEXTRIN
(FR) COMPLEXE D'INCLUSION D'INHIBITEUR DE FACTEUR Xa AVEC CYCLODEXTRINE
Abstract: front page image
(EN)An injectable Factor Xa inhibitor formulation is provided which includes the Factor Xa inhibitor razaxaban or apixaban, a solubilizing agent which is a substituted β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBE-CD) or hydroxypropyl-β-cyclodextrin (HPB-CD), and water. A method for preventing or treating venous thrombosis, deep venous thrombosis and acute coronary syndrome employing the above formulation is also provided.
(FR)La présente invention se rapporte à une formulation d'inhibiteur de Facteur Xa injectable qui renferme l'inhibiteur de Facteur Xa razaxaban ou apixaban, un agent de solubilisation qui est une β-cyclodextrine substituée, de préférence, une sulfobutyle éther β-cyclodextrine (SBE-CD) ou une hydroxypropyle-β-cyclodextrine (HPB-CD), et de l'eau. La présente invention concerne également une méthode permettant de prévenir ou de traiter la thrombose veineuse, la thrombose veineuse profonde et le syndrome coronarien aigu au moyen de la formulation ci-dessus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)