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Machine translation
1. (WO2007022012) DIFFERENTIALLY PROTECTED ORTHOGONAL LANTHIONINE TECHNOLOGY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/022012    International Application No.:    PCT/US2006/031510
Publication Date: 22.02.2007 International Filing Date: 11.08.2006
IPC:
C07K 1/107 (2006.01), C07K 14/315 (2006.01)
Applicants: ORAGENICS, INC. [US/US]; 12085 Research Drive, Alachua, FL 33615 (US) (For All Designated States Except US).
HILLMAN, Jeffrey, D. [US/US]; (US) (For US Only).
ORUGUNTY, Ravi, S. [IN/US]; (US) (For US Only).
SMITH, James, Leif [US/US]; (US) (For US Only)
Inventors: HILLMAN, Jeffrey, D.; (US).
ORUGUNTY, Ravi, S.; (US).
SMITH, James, Leif; (US)
Agent: OSLICK, Sherri, L.; MCDONNELL BOEHNEN HULBERT & BERGHOFF LLP, 300 South Wacker Drive, Suite 3200, Chicago, IL 60606 (US)
Priority Data:
60/708,086 12.08.2005 US
60/808,907 26.05.2006 US
Title (EN) DIFFERENTIALLY PROTECTED ORTHOGONAL LANTHIONINE TECHNOLOGY
(FR) TECHNOLOGIE LANTHIONINE ORTHOGONALE PROTÉGÉE DE MANIÈRE DIFFÉRENTIELLE
Abstract: front page image
(EN)The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two embedded rings. The present invention also provides methods for synthesizing lantibiotics, including Nisin A. Additionally, the invention provides intramolecularly bridged polypeptides synthesized by the methods disclosed herein and differentially protected orthogonal lanthionines.
(FR)La présente invention concerne un procédé de synthétisation d’un polypeptide à pontage intramoléculaire comprenant au moins un pont intramoléculaire. La présente invention concerne également un procédé de synthétisation d’un polypeptide à pontage intramoléculaire comprenant deux ponts intramoléculaires, où les deux ponts intramoléculaires forment deux anneaux se chevauchant, deux anneaux en série, ou deux anneaux combinés. La présente invention concerne également des procédés de synthétisation d’antibiotiques, englobant la Nisine A. En outre, l’invention concerne des polypeptides à pontage intramoléculaire synthétisés au moyen des procédés divulgués ici, et des lanthionines orthogonales protégées de manière différentielle.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)