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Machine translation
1. (WO2007021661) LIGANDS OF SH3 DOMAINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/021661    International Application No.:    PCT/US2006/030799
Publication Date: 22.02.2007 International Filing Date: 08.08.2006
IPC:
C07K 7/06 (2006.01), A61K 38/08 (2006.01)
Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY [US/US]; 1300 Morris Park Avenue, Bronx, NY 10461 (US) (For All Designated States Except US).
LAWRENCE, David, S. [US/US]; (US) (For US Only)
Inventors: LAWRENCE, David, S.; (US)
Agent: ARNOLD, Craig, J.; Amster, Rothstein & Ebenstein LLP, 90 Park Avenue, New York, NY 10016 (US)
Priority Data:
60/707,799 11.08.2005 US
Title (EN) LIGANDS OF SH3 DOMAINS
(FR) LIGANDS DES DOMAINES SH3
Abstract: front page image
(EN)Provided are compounds that bind to SH3 domains. Also provided are combinatorial libraries for discovering such compounds. Methods of identifying a compound that binds to an SH3 domain are also provided. Methods of inhibiting an activity of a protein comprising an SH3 domain are additionally provided. Additionally provided are methods of inhibiting the activity of a protein comprising an SH3 domain and methods of treating a mammal having a deleterious condition that is mediated by a protein comprising an SH3 domain. The use of a compound that binds to the SH3 domain of a protein kinase in the manufacture of a medicament for the treatment of a deleterious condition in a mammal that is dependent on a protein kinase for induction or severity are also provided.
(FR)La présente invention concerne des composés qui se lient aux domaines SH3. Cette invention concerne également des bibliothèques combinatoires permettant de découvrir de tels composés. Cette invention concerne en outre des procédés d'identification d'un composé qui se lie à un domaine SH3; des procédés d'inhibition d'une activité d'une protéine comprenant un domaine SH3; des procédés d'inhibition de l'activité d'une protéine comprenant un domaine SH3 et des procédés de traitement d'un mammifère présentant un état délétère induit par une protéine comprenant un domaine SH3. Cette invention concerne enfin l'utilisation d'un composé qui se lie au domaine SH3 d'une protéine kinase dans la fabrication d'un médicament servant au traitement, chez un mammifère, d'un état délétère dont l'induction ou la gravité dépendent d'une protéine kinase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)