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Machine translation
1. (WO2007021574) BICYCLIC PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/021574    International Application No.:    PCT/US2006/030393
Publication Date: 22.02.2007 International Filing Date: 04.08.2006
IPC:
C07D 471/04 (2006.01), C07D 487/04 (2006.01), A61K 31/4985 (2006.01), A61P 25/00 (2006.01), A61P 1/00 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Sodertalje (SE) (For All Designated States Except US).
EDWARDS, Louise [CA/CA]; (CA) (For US Only).
ISAAC, Methvin [CA/CA]; (CA) (For US Only).
SLASSI, Abdelmalik [CA/CA]; (CA) (For US Only).
SUN, Guang-Ri [CA/CA]; (CA) (For US Only).
XIN, Tao [CA/CA]; (CA) (For US Only).
MINIDIS, Alexander [SE/SE]; (SE) (For US Only).
DOVE, Peter [CA/CA]; (CA) (For US Only)
Inventors: EDWARDS, Louise; (CA).
ISAAC, Methvin; (CA).
SLASSI, Abdelmalik; (CA).
SUN, Guang-Ri; (CA).
XIN, Tao; (CA).
MINIDIS, Alexander; (SE).
DOVE, Peter; (CA)
Agent: MEIKLE, Andrew, D.; c/o Birch, Stewart, Kolasch & Birch, LLP, P.O. Box 747, Falls Church, VA 22040-0747 (US)
Priority Data:
60/707,945 15.08.2005 US
Title (EN) BICYCLIC PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
(FR) PIPERAZINES BICYCLIQUES EN TANT QU'AGENTS ANTAGONISTES DE RECEPTEUR DE GLUTAMATE METABOTROPIQUE
Abstract: front page image
(EN)The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.
(FR)L'invention concerne des composés de formule I ou des sels pharmaceutiquement acceptables ou des solvates de ceux-ci: où Ar1, A Hy, R1, m et n sont tels que définis dans la description. L'invention porte également sur des compositions pharmaceutiques et des utilisations de celles-ci, sur des procédés de fabrication desdits composés ainsi que sur des procédés de traitement médical de troubles médiés par mGluR5.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)