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1. (WO2007021101) SUSTAINED-RELEASE PELLET FORMULATION OF ALPHA1-RECEPTOR ANTAGONIST AND PROCESS FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/021101    International Application No.:    PCT/KR2006/003156
Publication Date: 22.02.2007 International Filing Date: 11.08.2006
IPC:
A61K 9/28 (2006.01), A61K 9/22 (2006.01)
Applicants: AMOREPACIFIC CORPORATION [KR/KR]; 181, 2-ga Hangang-ro, Yongsan-gu, Seoul 140-777 (KR) (For All Designated States Except US).
SHIN, Kwang Hyun [KR/KR]; (KR) (For US Only).
SHIN, Young Hee [KR/KR]; (KR) (For US Only).
BIN, Sung Ah [KR/KR]; (KR) (For US Only).
KIM, Jung Ju [KR/KR]; (KR) (For US Only)
Inventors: SHIN, Kwang Hyun; (KR).
SHIN, Young Hee; (KR).
BIN, Sung Ah; (KR).
KIM, Jung Ju; (KR)
Agent: JANG, Seongku; 19th Fl., Trust Tower, #275-7, Yangjae-dong, Seocho-ku, Seoul 137-130 (KR)
Priority Data:
10-2005-0076449 19.08.2005 KR
Title (EN) SUSTAINED-RELEASE PELLET FORMULATION OF ALPHA1-RECEPTOR ANTAGONIST AND PROCESS FOR THE PREPARATION THEREOF
(FR) FORMULATION DE GRANULES A LIBERATION PROLONGEE D'UN ANTAGONISTE DES RECEPTEURS $G(A)1, ET PROCEDE DE PREPARATION DE CELLE-CI
Abstract: front page image
(EN)A sustained-release pellet formulation comprising: a pellet core comprising an &agr;1-receptor antagonist, a pellet-forming susbstance and a pharmaceutically acceptable excipient and a coating layer comprising an enteric coating substance and a water-insoluble polymer, which is coated on said pellet core maintains a therapeutically effective drug level in the blood for a sufficient time without an initial burst and sustains the release of the drug even in the small intestine due to the water-insoluble polymer in the coating layer.
(FR)L'invention concerne une formulation de granulés à libération prolongée, qui comprend: un noyau de granulé comprenant un antagoniste des récepteurs $g(a)1, une matière formant des granulés et un excipient pharmaceutiquement acceptable; et une couche d'enrobage comprenant une matière d'enrobage gastro-résistante et un polymère insoluble dans l'eau. Ladite couche, qui enrobe le noyau du granulé, permet de maintenir un taux sanguin thérapeutiquement efficace du médicament pendant une durée suffisante sans pic de libération initial, et permet une libération prolongée du médicament dans l'intestin grêle grâce au polymère insoluble dans l'eau, présent dans la couche d'enrobage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)