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1. (WO2007020936) BICYCLO HETEROCYCLIC COMPOUND HAVING ANTIFUNGAL ACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/020936    International Application No.:    PCT/JP2006/316085
Publication Date: 22.02.2007 International Filing Date: 16.08.2006
IPC:
C07D 263/56 (2006.01), A61K 31/4025 (2006.01), A61K 31/404 (2006.01), A61K 31/4184 (2006.01), A61K 31/423 (2006.01), A61K 31/427 (2006.01), A61K 31/428 (2006.01), A61K 31/4439 (2006.01), A61K 31/454 (2006.01), A61K 31/496 (2006.01), A61K 31/497 (2006.01), A61K 31/5377 (2006.01), A61P 31/10 (2006.01), C07D 263/58 (2006.01), C07D 403/04 (2006.01), C07D 405/04 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), C07D 417/04 (2006.01), C07D 417/14 (2006.01)
Applicants: DAIICHI SANKYO COMPANY, LIMITED [JP/JP]; 3-5-1, Nihonbachi Honcho Chuo-ku Tokyo 1038426 (JP) (For All Designated States Except US).
KAWAKAMI, Katsuhiro [JP/JP]; (JP) (For US Only).
KANAI, Kazuo [JP/JP]; (JP) (For US Only).
HORIUCHI, Takao [JP/JP]; (JP) (For US Only).
TAKESHITA, Hiroshi [JP/JP]; (JP) (For US Only).
KOBAYASHI, Syozo [JP/JP]; (JP) (For US Only).
SUGIMOTO, Yuichi [JP/JP]; (JP) (For US Only).
ACHIWA, Issei [JP/JP]; (JP) (For US Only).
KUROYANAGI, Junichi [JP/JP]; (JP) (For US Only)
Inventors: KAWAKAMI, Katsuhiro; (JP).
KANAI, Kazuo; (JP).
HORIUCHI, Takao; (JP).
TAKESHITA, Hiroshi; (JP).
KOBAYASHI, Syozo; (JP).
SUGIMOTO, Yuichi; (JP).
ACHIWA, Issei; (JP).
KUROYANAGI, Junichi; (JP)
Agent: OGURI, Shohei; Eikoh Patent Office, 7-13, Nishi-Shimbashi 1-chome, Minato-ku, Tokyo 1050003 (JP)
Priority Data:
2005-236837 17.08.2005 JP
2005-242786 24.08.2005 JP
Title (EN) BICYCLO HETEROCYCLIC COMPOUND HAVING ANTIFUNGAL ACTION
(FR) COMPOSÉ BICYCLIQUE HÉTÉROCYCLIQUE POSSÉDANT UNE ACTION FONGICIDE
(JA) 抗真菌作用二環性複素環化合物
Abstract: front page image
(EN)It is intended to provide a 1,6-β-glucan synthase inhibitor which strongly inhibits proliferation and has a high safety. It is intended to provide a compound which can specifically or selectively expressing an antifungal action on a broad spectrum based on the action mechanism of inhibiting the synthesis of 1,6-β-glucan. Further, it is intended to provide a drug, in particular, an antifungal agent containing the above compound, its salt or a hydrate thereof. More specifically speaking, a compound represented by the following general formula (I), its salt or a hydrate thereof; and a drug or an antifungal agent containing the above compound, its salt or a hydrate thereof.
(FR)La présente invention a pour but de fournir un inhibiteur de synthase du 1,6-β-glucan qui inhibe fortement sa prolifération et présente un niveau de sûreté élevé. Elle a pour but de fournir un composé qui peut spécifiquement ou sélectivement exprimer une action fongicide sur un vaste spectre basé sur le mécanisme de l'action d'inhibition de la synthèse du 1,6-β-glucan. En outre, elle est destinée à proposer un médicament, en particulier un agent fongicide contenant le composé mentionné ci-dessus, son sel ou l'hydrate correspondant. Plus spécifiquement parlant, il s'agit d'un composé représenté par la formule générale suivante (I), son sel ou l'hydrate correspondant et d'un médicament ou agent fongicide contenant le composé ci-dessus, son sel ou l'hydrate correspondant.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)