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1. (WO2007020871) TECHNIQUE FOR STABILIZATION OF YW753 REPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/020871 International Application No.: PCT/JP2006/315838
Publication Date: 22.02.2007 International Filing Date: 10.08.2006
IPC:
A61K 38/00 (2006.01) ,A61K 9/08 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/16 (2006.01) ,A61K 47/20 (2006.01) ,A61K 47/34 (2006.01) ,A61K 47/44 (2006.01)
Applicants: TODA, Atsushi[JP/JP]; JP (UsOnly)
AOKI, Hiroshi[JP/JP]; JP (UsOnly)
KOJIMA, Seiki[JP/JP]; JP (UsOnly)
NAKATA, Katsunori[JP/JP]; JP (UsOnly)
Astellas Pharma Inc.[JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 1038411, JP (AllExceptUS)
Inventors: TODA, Atsushi; JP
AOKI, Hiroshi; JP
KOJIMA, Seiki; JP
NAKATA, Katsunori; JP
Agent: MORITA, Hiroshi; c/o Astellas Pharma Inc., Intellectual Property, 3-11, Nishonbashi-Honcho 2-chome, Chuo-ku Tokyo 1038411, JP
Priority Data:
2005-23425612.08.2005JP
Title (EN) TECHNIQUE FOR STABILIZATION OF YW753 REPARATION
(FR) TECHNIQUE DE STABILISATION DE PREPARATION DE YW753
(JA) デプシペプチド含有注射液
Abstract:
(EN) [PROBLEMS] To provide an injection preparation which comprises a depsipeptide having a disulfide bond in the molecule, can be prepared in a simple manner, and is stable. [MEANS FOR SOLVING PROBLEMS] An injection preparation having an excellent long-term stability which can be prepared by replacing a solution containing a substance such as ferric chloride and having a pH value ranging from 7.0 to 1.0 inclusive, by nitrogen gas a solution, by nitrogen. [ADVANTAGES] The injection preparation is expected to be free from the formation of any aggregation or cluster of a depsipeptide having a double bond in the molecule and be excellent in storage stability.
(FR) La présente invention concerne une préparation d’injection comprenant un depsipeptide dont la molécule comporte une liaison bisulfure, pouvant être préparée de manière simple, et étant stable. La présente invention consiste en une préparation d'injection présentant une excellente stabilité à long terme, pouvant être préparée en remplaçant une solution, contenant une substance telle que du chlorure ferrique et ayant une valeur de pH comprise entre 7,0 et 1,0 inclus, par de l’azote. Cette préparation d’injection présente les avantages de ne pas avoir tendance à la formation d'agrégats ou de groupes de depsipeptides dont la molécule comporte une liaison disulfide, et d’avoir une excellente stabilité au stockage.
(JA) 【課題】分子内のジスルフィド結合を有するデプシペプチドを含有し、製造が容易でかつ安定な注射液製剤の提供。 【解決手段】塩化第二鉄等の物質を配合し、pHを7.0以下pH1.0以上とした液を窒素置換することにより、長期間の安定性に優れた注射液製剤の提供が可能となった。 【発明の効果】  本発明の注射液は、分子内に二重結合を有するデプシペプチドの凝集体、集合体の生成を回避し、保存性にも優れた注射剤の提供を可能とするものとして期待される。        
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)