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1. (WO2007020204) HFC SOLUTION FORMULATIONS FOR INHALATION CONTAINING SALBUTAMOL HYDROCHLORIDE OR SALBUTAMOL CITRATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/020204    International Application No.:    PCT/EP2006/065090
Publication Date: 22.02.2007 International Filing Date: 04.08.2006
IPC:
A61K 31/137 (2006.01), C07C 215/60 (2006.01), A61K 9/12 (2006.01)
Applicants: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Str. 173, 55216 Ingelheim am Rhein (DE) (For All Designated States Except US).
BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Str. 173, 55216 Ingelheim am Rhein (DE) (For All Designated States Except US).
SCHMIDT, Friedrich [DE/DE]; (DE) (For US Only).
MANN, Mariola [DE/DE]; (DE) (For US Only).
COPE, Michael [GB/GB]; (GB) (For US Only).
MEMMESHEIMER, Holger [DE/DE]; (DE) (For US Only)
Inventors: SCHMIDT, Friedrich; (DE).
MANN, Mariola; (DE).
COPE, Michael; (GB).
MEMMESHEIMER, Holger; (DE)
Agent: HAMMAN, Heinz; Boehringer Ingelheim GmbH, Binger Str. 173, 55216 Ingelheim Am Rhein (DE)
Priority Data:
05017599.1 12.08.2005 EP
Title (EN) HFC SOLUTION FORMULATIONS FOR INHALATION CONTAINING SALBUTAMOL HYDROCHLORIDE OR SALBUTAMOL CITRATE
(FR) FORMULATIONS D'HYDROFLUOROCARBONE EN SOLUTION CONTENANT DU CHLORHYDRATE DE SALBUTAMOL OU DU CITRATE DE SALBUTAMOL
Abstract: front page image
(EN)This invention relates to stabilized aerosol solution formulations containing acid addition salts of salbutamol, which are suitable for administration by metered dose inhalers (MDIs). More particularly, this invention relates to solution formulations containing one of the aforementioned salts of salbutamol, preferably salbutamol hydrochloride or salbutamol citrate, more preferably one of the two before mentioned salts in combination with one or more additional pharmacologically active substances, together with an environmentally safe hydrofluorocarbon (HFC) as a propellant, a co-solvent, preferably an organic compound as a co-solvent, and either an inorganic acid or an organic acid.
(FR)L'invention concerne des formulations en solution pour aérosol stabilisées contenant des sels d'addition d'acides de salbutamol, ces formulations pouvant être administrées par aérosol-doseur. L'invention concerne plus particulièrement des formulations en solution contenant un des sels de salbutamol susmentionnés, de préférence du chlorhydrate de salbutamol ou du citrate de salbutamol, idéalement un des deux sels précités en association avec une ou plusieurs autres substances pharmacologiquement actives, ainsi qu'un hydrofluorocarbone (HFC) sans danger pour l'environnement utilisé comme propulseur, un cosolvant, de préférence un composé organique comme cosolvant, et un acide inorganique ou un acide organique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)