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1. (WO2007019345) IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/019345 International Application No.: PCT/US2006/030511
Publication Date: 15.02.2007 International Filing Date: 04.08.2006
IPC:
C07D 471/04 (2006.01) ,A61K 31/435 (2006.01) ,A61P 3/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 27/00 (2006.01) ,A61P 39/00 (2006.01) ,A61P 7/00 (2006.01) ,A61P 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
Applicants: NUNES, Joseph, J.[US/US]; US (UsOnly)
MILNE, Jill[US/US]; US (UsOnly)
BEMIS, Jean[US/US]; US (UsOnly)
XIE, Roger[US/US]; US (UsOnly)
VU, Chi, B.[US/US]; US (UsOnly)
NG, Pui, Yee[US/US]; US (UsOnly)
DISCH, Jeremy, S.[US/US]; US (UsOnly)
SIRTRIS PHARMACEUTICALS, INC.[US/US]; 200 Technology Square, Suite 300 Cambridge, MA 02139, US (AllExceptUS)
Inventors: NUNES, Joseph, J.; US
MILNE, Jill; US
BEMIS, Jean; US
XIE, Roger; US
VU, Chi, B.; US
NG, Pui, Yee; US
DISCH, Jeremy, S.; US
Agent: VINCENT, Matthew, P. ; Fish & Neave IP Group, Ropes & Gray LLP One International Place Boston, MA 02110-2624, US
Priority Data:
60/705,61204.08.2005US
60/741,78302.12.2005US
60/779,37003.03.2006US
60/792,27614.04.2006US
Title (EN) IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS
(FR) DÉRIVÉS DE L’IMIDAZOPYRIDINE EN TANT QU’AGENTS MODULANT LA SIRTUINE
Abstract:
(EN) Provided herein are imidazopyridine derivatives of formulas ((XIV), (XV),(XVI) and (XVII) which are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
(FR) La présente invention se rapporte à des dérivés d’imidazopyridine des formules (XIV), (XV), (XVI) et (XVII), qui sont des composés modulant la sirtuine et leurs procédés d’utilisation. Les composés modulant la sirtuine peuvent être utilisés pour accroître la durée de vie d’une cellule, et traiter et/ou prévenir une grande variété de maladies et de troubles comprenant, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, au diabète, à l’obésité, aux maladies neurodégénérescentes, à une maladie cardiovasculaire, aux troubles de la coagulation sanguine, à l’inflammation, au cancer et/ou aux bouffées vasomotrices ainsi que des maladies ou des troubles qui tireraient avantage d’une activité mitochondriale accrue. L’invention se rapporte également à des compositions comprenant modulant la sirtuine en combinaison avec un autre agent thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)