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Pub. No.:    WO/2007/019273    International Application No.:    PCT/US2006/030368
Publication Date: 15.02.2007 International Filing Date: 03.08.2006
A61K 38/16 (2006.01), G01N 33/53 (2006.01), C07K 2/00 (2006.01)
Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY [US/US]; 1300 Morris Park Avenue, Bronx, NY 10461 (US) (For All Designated States Except US).
DAVIES, Peter [GB/US]; (US) (For US Only).
CONRAD, Christopher [US/US]; (US) (For US Only)
Inventors: DAVIES, Peter; (US).
CONRAD, Christopher; (US)
Agent: ARNOLD, Craig, J.; AMSTER, ROTHSTEIN & EBENSTEIN LLP, 90 Park Avenue, New York, NY 10016 (US)
Priority Data:
60/705,585 04.08.2005 US
Abstract: front page image
(EN)Methods of diagnosing a tauopathy and predicting whether a subject will develop a tauopathy are provided. Also provided are antibody preparations that specifically bind to tau phosphorylated at tyr394 and/or tyr310. Methods of inhibiting tau phosphorylation in a cell and methods of treating a subject having a tauopathy are additionally provided. Methods of treating a subject at risk for a tauopathy are also provided. Additionally, non-human mammals comprising a transgene encoding an abl tyrosine kinase are provided. Also provided are methods of evaluating whether a compound inhibits development of a tauopathy.
(FR)L'invention porte sur des procédés permettant de diagnostiquer une tauopathie et de prédire si un sujet développera ou non une tauopathie. L'invention concerne également des préparations d'anticorps qui se lient spécifiquement à une tau phosphorylée à l'emplacement tyr394 et/ou tyr310. L'invention se rapporte à des procédés permettant d'inhiber la phosphorylation de tau dans une cellule et à des procédés permettant de traiter un sujet atteint de tauopathie. L'invention porte également sur des procédés permettant de traiter un sujet susceptible de développer une tauopathie. L'invention concerne en outre des mammifères non humains comprenant un transgène codant une tyrosine kinase abl. L'invention porte enfin sur des procédés qui permettent d'évaluer si un composé inhibe ou non le développement d'une tauopathie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)