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Machine translation
1. (WO2007019232) IMMUNOCONJUGATE FORMULATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/019232    International Application No.:    PCT/US2006/030295
Publication Date: 15.02.2007 International Filing Date: 02.08.2006
IPC:
A61K 39/00 (2006.01), C07K 16/00 (2006.01)
Applicants: IMMUNOGEN, INC. [US/US]; 128 Sidney Street, Cambridge, Massachusetts 02139-4239 (US) (For All Designated States Except US).
ZHANG, Wei [CN/US]; (US) (For US Only).
FLEMMING, Michael S. [US/US]; (US) (For US Only).
AMPHLETT, Godfrey [US/US]; (US) (For US Only).
CHIH, Hung-Wei [CN/US]; (US) (For US Only).
BARTLETT, Elizabeth [US/US]; (US) (For US Only)
Inventors: ZHANG, Wei; (US).
FLEMMING, Michael S.; (US).
AMPHLETT, Godfrey; (US).
CHIH, Hung-Wei; (US).
BARTLETT, Elizabeth; (US)
Agent: MACK, Susan, J.; SUGHRUE MION, PLLC, 2100 Pennsylvania Ave., NW, Suite 800, Washington, DC 20037-3213 (US)
Priority Data:
60/704,902 03.08.2005 US
60/707,162 11.08.2005 US
60/746,454 04.05.2006 US
60/746,456 04.05.2006 US
Title (EN) IMMUNOCONJUGATE FORMULATIONS
(FR) FORMULATIONS D'IMMUNOCONJUGUÉ
Abstract: front page image
(EN)The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
(FR)L'invention concerne une formulation d'immunoconjugué sensiblement exempte de particules qui contient : un immunoconjugué et un ou plusieurs excipients choisis dans le groupe constitué de : sucrose ; polysorbate 20 ; polysorbate 80 ; cyclodextrine ; dextrose ; glycérol ; polyéthylèneglycol ; mannitol ; chlorure de sodium ; et un acide aminé. La formulation est une solution aqueuse tamponnée d'un pH de 4,5 à 7,6. L'invention concerne également une formulation d'immunoconjugué sensiblement exempte d'agrégats qui contient : un immunoconjugué et un ou plusieurs excipients choisis dans le groupe constitué de : histidine ; sucrose ; glycine ; et chlorure de sodium. La formulation est une solution aqueuse tamponnée d'un pH de 4,5 à 7,6. L'invention concerne enfin une formulation d'immunoconjugué sensiblement exempte aussi bien de particules que d'agrégats.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)