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1. (WO2007018843) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/018843    International Application No.:    PCT/US2006/026155
Publication Date: 15.02.2007 International Filing Date: 03.07.2006
IPC:
G01N 33/569 (2006.01), C07K 5/10 (2006.01), C07K 7/06 (2006.01), C07K 14/085 (2006.01), C07K 16/10 (2006.01), A61K 38/00 (2006.01), A61K 39/00 (2006.01), A61P 31/16 (2006.01)
Applicants: ARBOR VITA CORPORATION [US/US]; 772 Lucerne Drive, Sunnyvale, California 94085 (US) (For All Designated States Except US).
LU, Peter, S. [US/US]; (US) (For US Only).
RABINOWITZ, Joshua, D. [US/US]; (US) (For US Only).
BELMARES, Michael, P. [US/US]; (US) (For US Only)
Inventors: LU, Peter, S.; (US).
RABINOWITZ, Joshua, D.; (US).
BELMARES, Michael, P.; (US)
Agent: HAYNES, Jennifer; Two Embarcadero Center, 8th Floor, San Francisco, California 94111-3834 (US)
Priority Data:
60/696,221 01.07.2005 US
60/726,377 13.10.2005 US
60/765,292 02.02.2006 US
60/792,274 14.04.2006 US
Title (EN) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA
(FR) METHODES ET COMPOSITIONS DE DIAGNOSTIC ET DE TRAITEMENT DE LA GRIPPE
Abstract: front page image
(EN)The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.
(FR)L'invention porte: sur une méthode et des compositions permettant de déterminer la présence et la quantité d'un virus de la grippe dans un échantillon, dont les souches à haut risque de la grippe A; et sur des méthodes permettant de déterminer si un sujet est infecté par un virus de la grippe et le type de souche du virus. Ces méthodes consistent à mettre en contact un échantillon prélevé sur le sujet avec des polypeptides PDZ (PDZ) et/ou des ligands du PDZ (PL), puis à déterminer si des interactions de fixation se produisent entre eux. L'invention porte également sur des bioessais d'identification d'agents antiviraux et sur des méthodes d'utilisation de compositions modifiant la fixation du PDZ sur le PL dans des cellules infectées par le virus de la grippe.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)