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1. (WO2007018320) AGENT FOR PREVENTION OF GRAFT LOSS, AND SCREENING METHOD FOR THE AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/018320    International Application No.:    PCT/JP2006/316196
Publication Date: 15.02.2007 International Filing Date: 11.08.2006
IPC:
A61K 45/00 (2006.01), A61K 31/7032 (2006.01), A61P 37/06 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: RIKEN [JP/JP]; 2-1, Hirosawa, Wako-shi, Saitama 3510198 (JP) (For All Designated States Except US).
FUKUOKA UNIVERSITY [JP/JP]; 19-1, Nanakuma 8-chome, Jonan-ku, Fukuoka-shi, Fukuoka 8140180 (JP) (For All Designated States Except US).
KOJO, Satoshi [JP/JP]; (JP) (For US Only).
TANIGUCHI, Masaru [JP/JP]; (JP) (For US Only).
YASUNAMI, Yohichi [JP/JP]; (JP) (For US Only)
Inventors: KOJO, Satoshi; (JP).
TANIGUCHI, Masaru; (JP).
YASUNAMI, Yohichi; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg. 1-1, Fushimimachi 4-chome Chuo-ku, Osaka-shi Osaka 541-0044 (JP)
Priority Data:
2005-233250 11.08.2005 JP
Title (EN) AGENT FOR PREVENTION OF GRAFT LOSS, AND SCREENING METHOD FOR THE AGENT
(FR) AGENT POUR PRÉVENIR LA PERTE DE GREFFE ET MÉTHODE DE SÉLECTION DE L'AGENT
(JA) 移植片喪失の予防剤、及びそのスクリーニング方法
Abstract: front page image
(EN)Disclosed is an agent for prevention of graft loss comprising an NKT cell ligand such as &agr;-galactosylceramide. The agent can prevent the graft loss in clinical islet transplantation or the like, and therefore can contribute to the improvement in transplantation efficiency. Also disclosed is a method for screening a compound for use in the prevention/treatment of graft loss, which comprises selecting a compound capable of inhibiting the activation of an NKT cell, the production of IFN-ϝ in a CD11b+ cell or the like. By using the method, it becomes possible to produce an agent for preventing/treating premature graft loss by a novel mechanism.
(FR)L’invention concerne un agent permettant de prévenir la perte de greffe qui comprend un ligand de cellule NKT tel que l’&agr;-galactosylcéramide. L'agent peut empêcher la perte de greffe dans la transplantation d'îlot clinique ou similaire et peut par conséquent contribuer à améliorer l’efficacité de la transplantation. L’invention concerne aussi une méthode pour sélectionner un composé à utiliser dans la prévention/le traitement de la perte de greffe ; celle-ci comprend la sélection d’un composé capable d'inhiber l'activation d'une cellule NKT, la production d'IFN-ϝ dans une cellule CD11b+ ou similaire. Cette méthode permet de produire un agent pour prévenir/traiter la perte prématurée de greffe par un nouveau mécanisme.
(JA)本発明は、α−ガラクトシルセラミド等のNKT細胞リガンドを含有してなる、移植片喪失の予防剤を提供する。本発明の予防剤を用いれば、臨床における膵島移植等における移植片喪失を予防することが可能であるので、移植効率の向上に寄与し得る。また、NKT細胞の活性化、CD11b細胞のIFN−γ産生等を抑制し得る化合物を選択することを含む、移植片喪失の予防・治療用化合物のスクリーニング方法が提供される。本発明のスクリーニング方法を用いれば、新たなメカニズムによる早期移植片喪失の予防・治療薬を創出することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)