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1. (WO2007018259) METHOD FOR PURIFICATION OF CYTIDINEDIPHOSPHORIC CHOLINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/018259    International Application No.:    PCT/JP2006/315802
Publication Date: 15.02.2007 International Filing Date: 10.08.2006
IPC:
C07H 19/10 (2006.01), C12P 19/32 (2006.01)
Applicants: KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome, Chiyoda-ku, Tokyo 1008185 (JP) (For All Designated States Except US).
MURATA, Hideki; (For US Only).
MOKUDAI, Tsuyoshi; (For US Only).
SHIOMI, Michio; (For US Only)
Inventors: MURATA, Hideki; .
MOKUDAI, Tsuyoshi; .
SHIOMI, Michio;
Priority Data:
2005-231958 10.08.2005 JP
Title (EN) METHOD FOR PURIFICATION OF CYTIDINEDIPHOSPHORIC CHOLINE
(FR) PROCÉDÉ DE PURIFICATION DE LA CYTIDINE DIPHOSPHOCHOLINE
(JA) シチジンジリン酸コリンの精製方法
Abstract: front page image
(EN)A method for purification of cytidinediphosphoric choline comprising the steps of contacting a cytidinediphosphoric choline solution having a pH of 0.5 to 5.0 (inclusive) and containing a nucleic acid analogue with a H-type strongly acidic cation exchange resin, and eluting cytidinediphosphoric choline adsorbed on the resin with water or an aqueous solution having an ion concentration of 0.1 mol/L or lower to thereby isolate and purify cytidinediphosphoric choline.
(FR)La présente invention concerne un procédé de purification de la cytidine diphosphocholine. Ledit procédé comprend les étapes suivantes : mise en contact d'une solution de cytidine diphosphocholine ayant un pH de 0,5 à 5,0 (inclus) et contenant un analogue d'acide nucléique avec une résine échangeuse de cations fortement acide de type H et élution de la cytidine diphosphocholine adsorbée sur la résine avec de l'eau ou avec une solution aqueuse ayant une concentration en ions inférieure ou égale à 0,1 mol/l dans le but d'isoler et de purifier la cytidine diphosphocholine.
(JA) 核酸類縁物質を含む、pHが0.5以上5.0以下のシチジンジリン酸コリン溶液を、H形強酸性カチオン交換樹脂と接触させ、該樹脂に吸着したシチジンジリン酸コリンを水またはイオン濃度が0.1mol/L以下の水溶液で溶出させて、シチジンジリン酸コリンを分離精製することを特徴とするシチジンジリン酸コリンの精製方法を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)