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1. WO2007017687 - EP2 RECEPTOR AGONISTS

Publication Number WO/2007/017687
Publication Date 15.02.2007
International Application No. PCT/GB2006/002979
International Filing Date 09.08.2006
IPC
C07D 307/42 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
34having two or three double bonds between ring members or between ring members and non-ring members
38with substituted hydrocarbon radicals attached to ring carbon atoms
40Radicals substituted by oxygen atoms
42Singly bound oxygen atoms
C07D 307/54 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
34having two or three double bonds between ring members or between ring members and non-ring members
38with substituted hydrocarbon radicals attached to ring carbon atoms
54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 307/91 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
91Dibenzofurans; Hydrogenated dibenzofurans
C07D 213/70 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
70Sulfur atoms
C07D 263/56 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
C07C 233/80 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
80with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
CPC
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
06Antiabortive agents; Labour repressants
Applicants
  • ASTERAND UK LIMITED [GB]/[GB] (AllExceptUS)
  • OXFORD, Alexander, William [GB]/[GB] (UsOnly)
  • DAVIS, Richard, Jon [GB]/[GB] (UsOnly)
  • COLEMAN, Robert, Alexander [GB]/[GB] (UsOnly)
  • CLARK, Kenneth, Lyle [GB]/[GB] (UsOnly)
  • CLARK, David, Edward [GB]/[GB] (UsOnly)
  • HARRIS, Neil, Victor [GB]/[GB] (UsOnly)
  • FENTON, Garry [GB]/[GB] (UsOnly)
  • HYND, George [GB]/[GB] (UsOnly)
  • STUTTLE, Keith, Alfred, James [GB]/[GB] (UsOnly)
  • SUTTON, Jonathan, Mark [GB]/[GB] (UsOnly)
  • ASHTON, Mark, Richard [GB]/[GB] (UsOnly)
  • BOYD, Edward, Andrew [GB]/[GB] (UsOnly)
  • BRUNTON, Shirley, Ann [GB]/[GB] (UsOnly)
Inventors
  • OXFORD, Alexander, William
  • DAVIS, Richard, Jon
  • COLEMAN, Robert, Alexander
  • CLARK, Kenneth, Lyle
  • CLARK, David, Edward
  • HARRIS, Neil, Victor
  • FENTON, Garry
  • HYND, George
  • STUTTLE, Keith, Alfred, James
  • SUTTON, Jonathan, Mark
  • ASHTON, Mark, Richard
  • BOYD, Edward, Andrew
  • BRUNTON, Shirley, Ann
Agents
  • WATSON, Robert
Priority Data
0516439.710.08.2005GB
60/706,43109.08.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) EP2 RECEPTOR AGONISTS
(FR) AGONISTES DES RECEPTEURS EP2
Abstract
(EN) A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; L' is a single bond, -O- or -C(=O)-; A is selected from the group consisting of: formulae (i) (ii) (iii) wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formulae (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix) B is selected from the group consisting of: formulae (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) -CO2H; (ii) -CONH2; (iii) -CH2-OH; or (iv) tetrazol-5-yl.
(FR) L'invention concerne un composé représenté par la formule (III) ou un sel, un solvate ou une forme chimiquement protégée de celui-ci. Dans la formule (III), R5 représente un groupe C5-20 aryle ou C4-20 alkyle éventuellement substitué; L' représente une liaison simple, -O- ou -C(=O)-; A est sélectionné dans le groupe constitué par les formules (i) (ii) (iii) dans lesquelles X et Y sont sélectionnés dans le groupe constitué par O et CR3; S et CR3; NH et CR3; NH et N; O et N; S et N; N et S; et N et O, les lignes en pointillé indiquant une liaison double à l'emplacement approprié, et Q représentant N ou CH; D est sélectionné dans les formules (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix); B est sélectionné dans le groupe constitué par les formules (A) (B), RP6 étant sélectionné dans le groupe constitué par fluoro et chloro; et R2 représentant soit (i) -CO2H; (ii) -CONH2; (iii) -CH2-OH; soit (iv) tetrazol-5-yl.
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PH12008500355This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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