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1. (WO2007017687) EP2 RECEPTOR AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/017687 International Application No.: PCT/GB2006/002979
Publication Date: 15.02.2007 International Filing Date: 09.08.2006
IPC:
C07D 307/42 (2006.01) ,C07D 307/54 (2006.01) ,C07D 307/91 (2006.01) ,C07D 213/70 (2006.01) ,C07D 263/56 (2006.01) ,C07C 233/80 (2006.01) ,C07C 257/18 (2006.01) ,A61K 31/4418 (2006.01) ,A61P 11/06 (2006.01) ,C07D 405/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
38
with substituted hydrocarbon radicals attached to ring carbon atoms
40
Radicals substituted by oxygen atoms
42
Singly bound oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
38
with substituted hydrocarbon radicals attached to ring carbon atoms
54
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
91
Dibenzofurans; Hydrogenated dibenzofurans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62
Oxygen or sulfur atoms
70
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52
condensed with carbocyclic rings or ring systems
54
Benzoxazoles; Hydrogenated benzoxazoles
56
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
80
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
257
Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
10
with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
18
having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4418
having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
OXFORD, Alexander, William [GB/GB]; GB (UsOnly)
DAVIS, Richard, Jon [GB/GB]; GB (UsOnly)
COLEMAN, Robert, Alexander [GB/GB]; GB (UsOnly)
CLARK, Kenneth, Lyle [GB/GB]; GB (UsOnly)
CLARK, David, Edward [GB/GB]; GB (UsOnly)
HARRIS, Neil, Victor [GB/GB]; GB (UsOnly)
FENTON, Garry [GB/GB]; GB (UsOnly)
HYND, George [GB/GB]; GB (UsOnly)
STUTTLE, Keith, Alfred, James [GB/GB]; GB (UsOnly)
SUTTON, Jonathan, Mark [GB/GB]; GB (UsOnly)
ASHTON, Mark, Richard [GB/GB]; GB (UsOnly)
BOYD, Edward, Andrew [GB/GB]; GB (UsOnly)
BRUNTON, Shirley, Ann [GB/GB]; GB (UsOnly)
ASTERAND UK LIMITED [GB/GB]; 2 Orchard Road Royston Hertfordshire SG8 5HD, GB (AllExceptUS)
Inventors:
OXFORD, Alexander, William; GB
DAVIS, Richard, Jon; GB
COLEMAN, Robert, Alexander; GB
CLARK, Kenneth, Lyle; GB
CLARK, David, Edward; GB
HARRIS, Neil, Victor; GB
FENTON, Garry; GB
HYND, George; GB
STUTTLE, Keith, Alfred, James; GB
SUTTON, Jonathan, Mark; GB
ASHTON, Mark, Richard; GB
BOYD, Edward, Andrew; GB
BRUNTON, Shirley, Ann; GB
Agent:
WATSON, Robert ; Mewburn Ellis LLP York House 23 Kingsway Greater London London WC2B 6HP, GB
Priority Data:
0516439.710.08.2005GB
60/706,43109.08.2005US
Title (EN) EP2 RECEPTOR AGONISTS
(FR) AGONISTES DES RECEPTEURS EP2
Abstract:
(EN) A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; L' is a single bond, -O- or -C(=O)-; A is selected from the group consisting of: formulae (i) (ii) (iii) wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formulae (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix) B is selected from the group consisting of: formulae (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) -CO2H; (ii) -CONH2; (iii) -CH2-OH; or (iv) tetrazol-5-yl.
(FR) L'invention concerne un composé représenté par la formule (III) ou un sel, un solvate ou une forme chimiquement protégée de celui-ci. Dans la formule (III), R5 représente un groupe C5-20 aryle ou C4-20 alkyle éventuellement substitué; L' représente une liaison simple, -O- ou -C(=O)-; A est sélectionné dans le groupe constitué par les formules (i) (ii) (iii) dans lesquelles X et Y sont sélectionnés dans le groupe constitué par O et CR3; S et CR3; NH et CR3; NH et N; O et N; S et N; N et S; et N et O, les lignes en pointillé indiquant une liaison double à l'emplacement approprié, et Q représentant N ou CH; D est sélectionné dans les formules (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix); B est sélectionné dans le groupe constitué par les formules (A) (B), RP6 étant sélectionné dans le groupe constitué par fluoro et chloro; et R2 représentant soit (i) -CO2H; (ii) -CONH2; (iii) -CH2-OH; soit (iv) tetrazol-5-yl.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)