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1. (WO2007017154) HUMAN INHIBITORY ANTI-FACTOR VIII ANTIBODIES BINDING TO THE A2 DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/017154    International Application No.:    PCT/EP2006/007564
Publication Date: 15.02.2007 International Filing Date: 31.07.2006
Chapter 2 Demand Filed:    29.05.2007    
IPC:
C07K 16/36 (2006.01), A61K 39/395 (2006.01), A61P 7/02 (2006.01)
Applicants: LIFE SCIENCES RESEARCH PARTNERS VZW [BE/BE]; Herestraat 49, bus 913, B-3000 Leuven (BE) (For All Designated States Except US).
JACQUEMIN, Marc [BE/BE]; (BE) (For US Only).
GILLES, Jean, Guy [BE/BE]; (BE) (For US Only).
SAINT-REMY, Jean-Marie [BE/BE]; (BE) (For US Only)
Inventors: JACQUEMIN, Marc; (BE).
GILLES, Jean, Guy; (BE).
SAINT-REMY, Jean-Marie; (BE)
Agent: BIRD, William, E.; Bird Goën & Co., Klein Dalenstraat 42A, B-3020 Winksele (BE)
Priority Data:
0515637.7 29.07.2005 GB
0516055.1 04.08.2005 GB
Title (EN) HUMAN INHIBITORY ANTI-FACTOR VIII ANTIBODIES BINDING TO THE A2 DOMAIN
(FR) NOUVEAUX ANTICORPS ANTI-FACTEUR VIII
Abstract: front page image
(EN)The present invention relates to new antibodies and fragments and derivatives thereof, which are particularly suited for the characterization of the structure and function of Factor VIII (FVIII) of the coagulation pathway, for the design of therapeutic strategies for eradication of FVIII inhibitors and for the use as a medicament. The invention also relates to cell lines producing the specific antibodies. The present invention furthermore relates to pharmaceutical compositions comprising the antibodies, fragments and/or derivatives of the invention and to methods of preventing and treating cardiovascular disorders by using the antibodies or fragments and derivatives thereof or pharmaceutical compositions thereof.
(FR)L'invention concerne de nouveaux anticorps, leurs fragments et dérivés, particulièrement adaptés pour caractériser la structure et la fonction du facteur VIII (FVIII) du trajet de coagulation, dans le but de concevoir des stratégies thérapeutiques servant à éradiquer des inhibiteurs de FVIII, ainsi qu'à l'utiliser sous forme de médicament. Elle concerne également des lignées cellulaires produisant ces anticorps spécifiques. Elle concerne, de plus, des compositions pharmaceutiques contenant ces anticorps, leurs fragments et/ou dérivés, et des méthodes permettant de prévenir et de traiter des troubles cardio-vasculaires au moyen de ces anticorps, de leurs fragments ou de leurs dérivés, ou de compositions pharmaceutiques à base de ces derniers.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)