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3. (WO2007016763) PEPTIDES TARGETED TO PROTEIN KINASE C ISOFORMS AND USES THEREOF

Pub. No.:    WO/2007/016763    International Application No.:    PCT/CA2006/001259
Publication Date: Fri Feb 16 00:59:59 CET 2007 International Filing Date: Tue Aug 08 01:59:59 CEST 2006
IPC: C07K 14/00
A61K 38/10
A61K 38/08
A61K 38/16
A61K 47/48
C07K 7/06
C07K 7/08
C12N 9/12
G01N 33/554
G01N 33/566
Applicants: PHARMAGAP INC.
PHIPPS, Jenny
TERREUX, Raphael
Inventors: PHIPPS, Jenny
TERREUX, Raphael
Title: PEPTIDES TARGETED TO PROTEIN KINASE C ISOFORMS AND USES THEREOF
Abstract:
Peptides having a sequence of general formula (I), or the retro form thereof, and having an affinity for one or more mammalian protein kinase C-alpha isoforms are provided: X-[(HY-HB)n-linker]m-(HB-HY)2-HB-(HY)m-Z (I) wherein: HY represents a block of 1 to 4 hydrophobic amino acid residues selected from the group of: Ala, GIy, He, Leu, Phe and VaI; HB represents a block of 1 to 4 amino acid residues capable of forming hydrogen bonds selected from the group of: Arg, Asn, Asp, GIu, GIn, Lys and Ser; 'linker' represents 1 to 4 Gly residues; n is 1, 2 or 3; m is 0 or 1; X represents the N-terminus of the peptide or a modified version thereof, and Z represents the C-terminus of the peptide or a modified version thereof. The peptides can be used as probes, screening agents, targeting agents, purification agents and diagnostic agents.